Seguici su acebook facebook Cerca nel sito:

Le ricerche di Gerona 2005

(13-04-2017) Dietary Choline Intake Is Directly Associated with Bone Mineral Density in the Hordaland Health Study.



Øyen J1,2,3, Gjesdal CG4,5, Karlsson T5, Svingen GF6, Tell GS2, Strand E5, Drevon CA7, Vinknes KJ7, Meyer K8, Ueland PM5,9, Nygård O6,10.
Author information
Abstract
Background: Choline is an important nutrient either obtained from a variety of foods or synthesized endogenously, and it is the precursor of betaine. We previously reported positive associations between plasma free choline and bone mineral density (BMD). Animal studies suggest an impact of dietary choline on bone metabolism, but the role of dietary intake of choline and betaine for human bone health is unknown.Objectives: The main aims were to examine the associations of dietary choline, choline species, and betaine with BMD and to study the relations between dietary and plasma free choline and betaine.Methods: Study subjects were participants in the Hordaland Health Study, including 2649 women and 1983 men (aged 46-49 or 71-74 y). BMD was measured by dual-energy X-ray absorptiometry, and dietary intake was obtained by using a validated 169-item food-frequency questionnaire. Risk associations were assessed by logistic regression and correlations by ρ (Spearman's bivariate rank order correlation).Results: Subjects in the lowest compared with the highest tertile of dietary total choline, free choline, glycerophosphocholine, phosphocholine, phosphatidylcholine, and sphingomyelin had a higher risk of low-femoral neck BMD, defined as the lowest BMD quintile. Particularly strong associations were found among middle-aged men for intake of free choline (OR: 1.83; 95% CI: 1.24, 2.69; P = 0.002) and glycerophosphocholine (OR: 2.13; 95% CI: 1.43, 3.16; P < 0.001) and among elderly women for total choline (OR: 1.96; 95% CI: 1.33, 2.88; P = 0.001) and phosphatidylcholine (OR: 1.94; 95% CI: 1.33, 2.84: P = 0.001) intake. No significant associations were observed between dietary betaine and BMD. Dietary total choline, free choline, glycerophosphocholine, phosphatidylcholine, and sphingomyelin correlated weakly with plasma free choline (ρ: 0.07, 0.05, 0.07, 0.07, and 0.05, respectively; P < 0.01). Dietary betaine correlated with plasma betaine (ρ: 0.23; P < 0.001).Conclusion: Dietary choline was positively associated with BMD in middle-aged and elderly participants.

Source: J Nutr. 2017 Mar 8. pii: jn243006. doi: 10.3945/jn.116.243006. [Epub ahead of print]

News

  • (15-12-2017) The health of your gut microbiome could predict your risk of heart disease, researchers find

    Leggi tutto

  • (15-12-2017) Le cellule del colon proliferano con l’obesità

    Leggi tutto

  • (15-12-2017) Healthy gut bacteria can protect you from just about ANY age-related disease, new study finds

    Leggi tutto

  • (15-12-2017) Donne in menopausa: i benefici dell’acqua gassata

    Leggi tutto

  • (14-12-2017) The effects of dietary protein intake on appendicular lean mass and muscle function in elderly men: a 10-wk randomized controlled trial.

    Leggi tutto

  • (14-12-2017) FDA torna indietro su benefici cardiaci delle proteine della soia

    Leggi tutto

  • (14-12-2017) A high-glycemic diet is associated with cerebral amyloid burden in cognitively normal older adults.

    Leggi tutto

  • (14-12-2017) Tè verde e tè nero in aiuto per perdere peso

    Leggi tutto

  • (13-12-2017) Breast milk the new CANCER cure? Scientists discover tumor-destroying molecules with astonishing properties

    Leggi tutto

  • (13-12-2017) Pressione alta: il rischio si riduce facendo spesso la sauna

    Leggi tutto

  • (13-12-2017) The brain and immune system prompt energy shortage in chronic inflammation and ageing.

    Leggi tutto

  • (13-12-2017) Ragazzini, già obesi e ossidati

    Leggi tutto

  • (12-12-2017) Nutrients in apples and grapes found to increase stamina

    Leggi tutto

  • (12-12-2017) Cancro al colon: attività fisica intensa rilascia molecola preventiva

    Leggi tutto

  • (12-12-2017) Association Between Adipokines Levels with Inflammatory Bowel Disease (IBD): Systematic Reviews.

    Leggi tutto

  • (11-12-2017) Anche in giovane età il rischio di morte è molto maggiore in presenza di diabete

    Leggi tutto

  • (11-12-2017) Sugar industry sponsorship of germ-free rodent studies linking sucrose to hyperlipidemia and cancer: An historical analysis of internal documents

    Leggi tutto

  • (11-12-2017) Diabete e obesità: in un anno hanno provocato 800.000 nuovi casi di tumore

    Leggi tutto

  • (11-12-2017) Vitamin D Deficiency

    Leggi tutto

  • (10-12-2017) Malattie infiammatorie intestinali. Forte legame con l’industrializzazione

    Leggi tutto

  • (10-12-2017) Circulating vitamin D concentration and age-related macular degeneration: Systematic review and meta-analysis

    Leggi tutto

  • (10-12-2017) Cuore a rischio per troppo zucchero

    Leggi tutto

  • (10-12-2017)n Memory and sleep: Researchers finally discover why getting sufficient sleep dramatically boosts brain performance

    Leggi tutto


In evidenza

"L'informazione presente nel sito serve a migliorare, e non a sostituire, il rapporto medico-paziente."

Per coloro che hanno problemi di salute si consiglia di consultare sempre il proprio medico curante.

Informazioni utili