Seguici su acebook facebook Cerca nel sito:

Le ricerche di Gerona 2005

(23-04-2017) A Prospective Study of Egg Consumption and Risk of Cardiovascular Disease in Men and Women




Frank B. Hu, MD; Meir J. Stampfer, MD; Eric B. Rimm, ScD; et alJoAnn E. Manson, MD; Alberto Ascherio, MD; Graham A. Colditz, MD; Bernard A. Rosner, PhD; Donna Spiegelman, ScD; Frank E. Speizer, MD; Frank M. Sacks, MD; Charles H. Hennekens, MD; Walter C. Willett, MD
Author Affiliations
Author Affiliations: Departments of Nutrition (Drs Hu, Stampfer, Rimm, Ascherio, Sacks, and Willet), Epidemiology (Drs Stampfer, Rimm, Manson, Ascherio, Spiegelman, Hennekens, and Willet), and Biostatistics (Drs Spiegelman and Rosner), Harvard School of Public Health; Channing Laboratory (Drs Stampfer, Rimm, Manson, Colditz, Rosner, Speizer, and Willet), and the Division of Preventive Medicine (Drs Manson and Hennekens), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.



Abstract
Context Reduction in egg consumption has been widely recommended to lower blood cholesterol levels and prevent coronary heart disease (CHD). Epidemiologic studies on egg consumption and risk of CHD are sparse.

Objective To examine the association between egg consumption and risk of CHD and stroke in men and women.

Design and Setting Two prospective cohort studies, the Health Professionals Follow-up Study (1986-1994) and the Nurses' Health Study (1980-1994).

Participants A total of 37,851 men aged 40 to 75 years at study outset and 80,082 women aged 34 to 59 years at study outset, free of cardiovascular disease, diabetes, hypercholesterolemia, or cancer.

Main Outcome Measures Incident nonfatal myocardial infarction, fatal CHD, and stroke corresponding to daily egg consumption as determined by a food-frequency questionnaire.

Results We documented 866 incident cases of CHD and 258 incident cases of stroke in men during 8 years of follow-up and 939 incident cases of CHD and 563 incident cases of stroke in women during 14 years of follow-up. After adjustment for age, smoking, and other potential CHD risk factors, we found no evidence of an overall significant association between egg consumption and risk of CHD or stroke in either men or women. The relative risks (RRs) of CHD across categories of intake were less than 1 per week (1.0), 1 per week (1.06), 2 to 4 per week (1.12), 5 to 6 per week (0.90), and ≥1 per day (1.08) (P for trend=.75) for men; and less than 1 per week (1.0), 1 per week (0.82), 2 to 4 per week (0.99), 5 to 6 per week (0.95), and ≥1 per day (0.82) (P for trend=.95) for women. In subgroup analyses, higher egg consumption appeared to be associated with increased risk of CHD only among diabetic subjects (RR of CHD comparing more than 1 egg per day with less than 1 egg per week among diabetic men, 2.02 [95% confidence interval, 1.05-3.87; P for trend=.04], and among diabetic women, 1.49 [0.88-2.52; P for trend=.008]).

Conclusions These findings suggest that consumption of up to 1 egg per day is unlikely to have substantial overall impact on the risk of CHD or stroke among healthy men and women. The apparent increased risk of CHD associated with higher egg consumption among diabetic participants warrants further research.

Elevated low-density lipoprotein (LDL) cholesterol is a major risk factor for coronary heart disease (CHD).1 Dietary cholesterol raises LDL cholesterol levels and causes atherosclerosis in numerous animal models.2 In controlled metabolic studies conducted in humans, dietary cholesterol raises levels of total and LDL cholesterol in blood,3,4 but the effects are relatively small compared with saturated and transfatty acids.5,6 Studies have found that individuals vary widely in their responses to dietary cholesterol based on monitoring their plasma levels.7,8 Prospective cohort studies on the relationship of dietary cholesterol with risk of CHD have been inconsistent, with a significant association found in some,9,10 but not in most studies.11- 17

To avoid elevations in blood cholesterol and reduce CHD risk, the public has been advised to consume no more than 300 mg/d of cholesterol and limit consumption of eggs, which contain about 213 mg of cholesterol per egg.1,18 However, eggs contain many other nutrients besides cholesterol, including unsaturated fats, essential amino acids, folate, and other B vitamins. In addition, consumption of eggs instead of carbohydrate-rich foods may raise high-density lipoprotein (HDL) cholesterol levels19,20 and decrease blood glycemic and insulinemic responses.21 For these reasons, it is useful to study directly the relationship of egg consumption with risk of CHD, but few epidemiologic studies have addressed this association.22- 24 In this article, we examine prospectively the association between egg consumption and risk of CHD and stroke in 2 large cohorts of men and women.

Source: JAMA. 1999;281(15):1387-1394. doi:10.1001/jama.281.15.1387

News

  • (18-07-2018) Keep your heart healthy by eating more arugula, spinach, and beets

    Leggi tutto

  • (18-07-2018) Prescrizioni inappropriate, lo studio: troppi antibiotici in gravidanza

    Leggi tutto

  • (18-07-2018) Psoriasis linked to gut health: Leaky gut could be caused by microbiome composition

    Leggi tutto

  • (18-07-2018) L'emicrania potrebbe essere scatenata dagli estrogeni anche negli uomini

    Leggi tutto

  • (17-07-2018) Both depression and obesity are on the rise – coincidence? These conditions are linked in many ways

    Leggi tutto

  • (17-07-2018) Assunzione alcolici aumenta la pressione sanguigna, ecco le categorie più a rischio

    Leggi tutto

  • (17-07-2018) Tomato extracts KILL stomach cancer cells, new study shows

    Leggi tutto

  • (17-07-2018) L'allergia alla penicillina causa un aumento del rischio di infezioni resistenti

    Leggi tutto

  • (16-07-2018) Garlic is good for your heart; it lowers your blood pressure

    Leggi tutto

  • (16-07-2018) Diabete, in situazione di stress aumenta rischio di attacco cardiaco e ictus

    Leggi tutto

  • (16-07-2018) High-dose ω-3 Fatty Acid Plus Vitamin D3 Supplementation Affects Clinical Symptoms and Metabolic Status of Patients with Multiple Sclerosis: A Randomized Controlled Clinical Trial.

    Leggi tutto

  • (16-07-2018) Malattie psoriasiche, la dieta può variare la gravità di presentazione nei pazienti in sovrappeso

    Leggi tutto

  • (15-07-2018) Are you familiar with these 20 herbs that can be used as medicine?

    Leggi tutto

  • (15-07-2018) La dieta migliore

    Leggi tutto

  • (15-07-2018) Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

    Leggi tutto

  • (15-07-2018) Miopia, individuati 161 geni che la favoriscono

    Leggi tutto

  • (14-07-2018) Carotenoids in human nutrition and health

    Leggi tutto

  • (14-07-2018) L’importanza dei carotenoidi

    Leggi tutto

  • (14-07-2018) Tips for reducing your risk of breast cancer at any age

    Leggi tutto

  • (14-07-2018) Tatuaggi, nelle persone immunodepresse possibili gravi complicanze

    Leggi tutto

  • (13-07-2018) Low amounts of testosterone put men at risk of chronic diseases, even if they’re young

    Leggi tutto

  • (13-07-2018) Disbiosi intestinale e rischio cardiovascolare: presentata una consensus

    Leggi tutto

  • (13-07-2018) Cut your risk for liver cancer by HALF by just increasing your vitamin D levels

    Leggi tutto

  • (13-07-2018) I disturbi correlati allo stress sono associati allo sviluppo di malattie autoimmuni successive

    Leggi tutto

  • (12-07-2018) Follow these simple tips to minimize your exposure to “obesogens” – everyday chemicals that make you fat

    Leggi tutto

  • (12-07-2018) La combinazione di solventi organici e predisposizione genetica aumenta il rischio di sclerosi multipla

    Leggi tutto

  • (12-07-2018) Brisk walking for 3 hours a week can reduce your risk of heart disease

    Leggi tutto

  • (12-07-2018) Il diuretico Idroclorotiazide può aumentare il rischio di melanoma

    Leggi tutto

  • (11-07-2018) Alzheimer’s disease and Dementia are two entirely different things

    Leggi tutto

  • (11-07-2018) Il microbiota intestinale può aiutare a predire le persone a più alto rischio di epatocarcinoma

    Leggi tutto

  • (11-07-2018) Eat more Swiss chard to enhance endurance and lower your blood pressure

    Leggi tutto

  • (11-07-2018) Bere una o più tazze di tè caldo riduce il rischio glaucoma del 74%

    Leggi tutto

  • (10-07-2018) CONFIRMED: Antidepressants and other drugs cause dementia

    Leggi tutto

  • (10-07-2018) La privazione del sonno associata a un maggiore propensione a ingerire più cibo

    Leggi tutto

  • (10-07-2018) Acupuncture can relieve neck pain, new study confirms

    Leggi tutto

  • (10-07-2018) I pomodori e le mele possono rallentare il declino della funzione polmonare. Benefici nella BPCO ?

    Leggi tutto

  • (09-07-2018) Heavy menstruation could be a symptom of an underlying condition that causes fertility problems

    Leggi tutto

  • (09-07-2018) Farmaci antibatterici: rischio di aritmie potenzialmente fatali con Azitromicina

    Leggi tutto

  • (09-07-2018) Children and pre-teens who lack sleep are 58% more likely to become obese as adults

    Leggi tutto

  • (09-07-2018) Associazione tra peso e mortalità negli adulti con diabete mellito

    Leggi tutto

  • (08-07-2018) 10 Yummy, brain-boosting foods that prevent neurocognitive decline

    Leggi tutto

  • (08-07-2018) Il brutto tempo influenza l’umore

    Leggi tutto

  • (08-07-2018) Autoimmune disease doesn’t have to take over your life

    Leggi tutto

  • (08-07-2018) Rughe? Frutta e verdura fresca meglio di creme

    Leggi tutto

  • (07-07-2018) Study: Consuming foods rich in omega-3 fatty acids cuts your risk of death by 33%

    Leggi tutto

  • (07-07-2018) Asma. L’uso di antibiotici prolunga la degenza in ospedale

    Leggi tutto

  • (07-07-2018) BUSTED: 8 sleep myths that actually make you more tired

    Leggi tutto

  • (07-07-2018) IL RUOLO DELLA VITAMINA D NEL CONTROLLO GLICEMICO

    Leggi tutto


In evidenza

"L'informazione presente nel sito serve a migliorare, e non a sostituire, il rapporto medico-paziente."

Per coloro che hanno problemi di salute si consiglia di consultare sempre il proprio medico curante.

Informazioni utili