(02-04-13) Effect of different dietary omega-3/omega-6 fatty acid ratios on reproduction in male rats.

Yan L, Bai XL, Fang ZF, Che LQ, Xu SY, Wu D.
Abstract
BACKGROUND:
Beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on the reproduction of male animals are widely described in the literature. However, there is little information about the effect of n-3/n-6 ratios on male health and reproduction. The aim of this study was to investigate the effects of diets with different omega-3/omega-6 polyunsaturated fatty acid (n-3/n-6 PUFA) ratios on the reproductive performance of male rats.
METHODS:
Eighty male Sprague Dawley (SD) rats were supplemented with diets containing different n-3/n-6 PUFA ratios (0.13, 0.40, 0.85, 1.52 and 2.85) for 60 days. Half of the rats in each group were sacrificed on day 60, and the other half were chosen to mate with female mice to assess the effects of n-3/n-6 ratios on reproductive performance.
RESULTS:
Sperm density and sperm motility of the 1.52 group were higher than other groups (P < .05), and the development of testis and the morphological structure of sperm in the 1.52 group were better than other groups. Furthermore, a higher litter size and birth weights of offspring were observed in the 1.52 group. Additionally, serum reproductive hormone levels were significantly affected by the n-3/n-6 ratios.
CONCLUSION:
These findings demonstrated that a balanced n-3/n-6 ratio was important in male rat reproduction. Therefore there is a necessity to determine an appropriate n-3/n-6 PUFA ratio in man and different male animals in the future.

Source: Lipids Health Dis. 2013 Mar 13;12(1):33. [Epub ahead of print]

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