(05-05-13) Melanoma breakthrough: Natural fruit and vegetable substance stops skin cancer cells

by Sherry Baker, Health Sciences Editor

(NaturalNews) Not all skin cancers are life-threatening but there is one form
-- melanoma -- which is difficult to treat successfully and can be deadly. A
type of cancer that begins in melanocytes (cells that make the pigment
melanin), it can start in a mole (skin melanoma), but can also begin in other
pigmented tissues, such as in the eye or even the intestines. According to the
National Cancer Institute, almost 77,000 new cases of melanoma are expected to
be diagnosed in the US this year.

Currently, there is no single therapeutic agent or combination treatment
available to treat all melanomas. About 9,480 Americans are predicted to die in
2013 from this malignancy which can spread throughout the body. But there's
good news on the research front about the disease. For the first time,
scientists have demonstrated that a natural substance, gossypin, found in
vegetables and fruits can halt melanoma cells - and they say they know why.

"We identified gossypin as a novel agent with dual inhibitory activity towards
two common mutations that are the ideal targets for melanoma treatment," Texas
Biomed's Hareesh Nair, Ph.D., who headed the research, said in a media
statement. "Our results indicate that gossypin may have great therapeutic
potential as a dual inhibitor of mutations called BRAFV600E kinase and CDK4,
which occur in the vast majority of melanoma patients."

Nair added that his research team's findings "... open a new avenue for the
generation of a novel class of compounds for the treatment of melanoma."

Natural substance blocks growth of melanoma cells
For the new study, just published in the journal Molecular Cancer
Therapeutics, Nair and his colleagues worked with human melanoma cells in the
lab. They found that gossypin inhibited human melanoma cell proliferation in
melanoma cell lines that harbor the two mutations, possibly by directly binding
with them.

What's more, the veggie and fruit derived substance inhibited the growth of a
variety human melanoma cells. In addition, in animal experiments using mice
transplanted with human melanoma cell tumors , gossypin treatment for 10 days
reduced tumor volume and increased survival rate.

Nair's team is now working to understand how the body absorbs gossypin and how
it is metabolized. In the media statement, the researchers noted discussions
are underway with the Cancer Therapy & Research Center at the University of
Texas Health Science Center about testing gossypin in melanoma patients.

Editor's note: NaturalNews is opposed to the use of animals in medical
experiments that expose them to harm. We present these findings in protest of
the way in which they were acquired.

Sources for this article include:

http://mct.aacrjournals.org

http://www.cancer.gov/cancertopics/types/melanoma

http://txbiomed.org

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