(17-05-13) Decreased neuromuscular function in Crohn's disease patients is not associated with low serum vitamin D levels.

Salacinski AJ, Regueiro MD, Broeder CE, McCrory JL.
Source
Department of Kinesiology and Physical Education, Northern Illinois
University, 204 Anderson Hall, DeKalb, IL 60115, USA. [email protected]
Abstract
BACKGROUND:
Neuromuscular fatigue is a common complaint in Crohn's disease (CD) patients.
A correlation between serum vitamin D concentrations and neuromuscular function
has been found in the elderly or non-ambulant populations.
AIMS:
The aim of this study was to determine whether CD patients exhibit impaired
neuromuscular function and if so, is there a link between vitamin D and
neuromuscular function.
METHODS:
Crohn's disease patients (n = 19) with at least one prior small bowel
resection and matched controls (n = 19) underwent muscle strength and endurance
testing, vitamin D, and nerve function analysis.
RESULTS:
Knee extension and flexion peak torque (Nm/kg) were greater in the control
group than in the CD patients (P = 0.04 and 0.014, respectively. A significant
difference was found between fatigue rates of the rectus femoris (P = 0.015)
between CD patients and controls, but no difference was found in serum vitamin
D levels between groups (P = 0.317). Knee extension and flexion torque
measurements, with age as a covariate, were compared with high and low vitamin
D levels. Those subjects with high serum vitamin D levels had a significantly
greater extension peak torque (P = 0.045) and extension average torque (Nm/kg)
(P = 0.014) than those with low levels.
CONCLUSION:
Crohn's disease patients with sufficient vitamin D levels experienced a 43 %
greater extension peak torque. Although vitamin D deficiency has been
associated with neuromuscular dysfunction, there were no differences in serum
vitamin D levels between the CD and healthy controls to explain the decreased
muscle strength.


Source: Dig Dis Sci. 2013 Feb;58(2):526-33. doi: 10.1007/s10620-012-2372-4. Epub 2012
Sep 5.

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