(02-06-13) Relation between Serum Free Fatty Acids and Adiposity, Insulin Resistance and Cardiovascular Risk Factors

Relation between Serum Free Fatty Acids and Adiposity, Insulin Resistance and Cardiovascular Risk Factors from Adolescence to Adulthood.

Frohnert BI, Jacobs DR Jr, Steinberger J, Moran A, Steffen LM, Sinaiko AR.
Source
Department of Pediatrics, Medical School and.
Abstract
The objective of this study was to describe longitudinal relations of serum
total free fatty acids (FFA) to insulin resistance (IR) and cardiovascular (CV)
risk factors from adolescence into adulthood. The cohort included participants
in a longitudinal study of obesity and IR with complete data, including
anthropometric measures, FFA, IR measured by euglycemic clamp, blood pressure,
fasting serum lipids and insulin at mean-ages 15 and 22 (N=207) and their
parents (N=272). FFA and IR were not significantly related at mean-age 15 but
were significantly related at mean-age 22. FFA did not relate to BMI at either
age. FFA at age 15 estimated IR at age 22. In parents (mean-age 51) FFA was
significantly correlated with BMI, percent body fat, systolic blood pressure,
LDL, and IR. Associations with all risk factors except IR in parents were
attenuated by adjustment for BMI. Most age 22 correlations with parents were
higher than corresponding age 15 correlations. This study finds that FFA is
associated with IR starting in young adulthood. The relation between FFA and CV
risk factors does not become significant until later adulthood. The results
support a significant impact of early metabolic dysfunction on later CV risk.

Source: Diabetes. 2013 May 13. [Epub ahead of print]

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