(29-09-13) Repeat intestinal resections increase the risk of recurrence of Crohn's disease.

Riss S, Schuster I, Papay P, Mittlböck M, Stift A.
Source
Department of General Surgery, Medical University of Vienna, Vienna, Austria. [email protected]
Abstract
BACKGROUND:
Which factors predict recurrence in patients with Crohn's disease in the era of immunosuppressive medications is still under debate.
OBJECTIVE:
The current study was conducted to assess long-term outcome after ileocolic resection for Crohn's disease and to define predictive factors for surgical relapse.
DESIGN:
This is a retrospective study.
SETTINGS:
The study was conducted in a tertiary referral center.
PATIENTS:
A consecutive cohort of patients (n = 203) with Crohn's disease who underwent ileocolic resection between 1997 and 2006 were analyzed. The mean follow-up time was 8.4 (±2.4) years.
MAIN OUTCOME MEASURES:
The cumulative probability for repeated intestinal resection for recurrent Crohn's disease was described by Kaplan-Meier curves. Predictors of surgical recurrence were analyzed by univariate tests.
RESULTS:
One hundred five patients (51.7%) were exposed to azathioprine/6-mercaptopurine, and 28 patients (13.8%) were exposed to tumor necrosis factor-α blockers after operation. During the follow-up period, 32 patients (15.8%) were reoperated on for disease recurrence. At 5 and 10 years after index surgery, 95.5% and 81.3% of the patients had reoperation-free survival. Previous resections for Crohn's disease (HR, 2.981; 95% CI, 1.411-6.29; p = 0.003) and urgent indication for surgery (HR, 2.729; 95% CI, 1.047-7.116; p = 0.03) were significant risk factors for reoperation. In addition, patients with postoperative complications following ileocolonic resection were more likely to require reoperation (HR, 1.712; 95% CI, 041-2.817; p = 0.03). In a multiple Cox regression model, previous intestinal resection for Crohn's disease remained significant (p = 0.0114) with a HR of 2.654 (95% CI, 1.246-5.654).
LIMITATIONS:
The limitation is the retrospective design of the study, with its potential selection bias.
CONCLUSION:
In the present analysis, previous intestinal resection for Crohn's disease was found to be an independent risk factor for surgical recurrence. Consequently, shorter surveillance intervals in this group of patients should be considered.

Source : Dis Colon Rectum. 2013 Jul;56(7):881-7. doi: 10.1097/DCR.0b013e31828cb80c.

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