(05-09-06)Plasma long-chain fatty acids and the degree of obesity in Italian children.

Scaglioni S, Verduci E, Salvioni M, Bruzzese MG, Radaelli G, Zetterstrom R, Riva E, Agostoni C.

Department of Paediatrics, University of Milan, Milan, Italy.

Aim: To examine whether the plasma levels of long-chain polyunsaturated fatty acids (LC-PUFAs) are associated with the degree of obesity in children. Methods: Sixty-seven normolipidaemic obese children, aged 8-12 y, and 67 age- and sex-matched normal-weight children were included in the study. Obesity was defined in accordance with the International Obesity Task Force. BMI z-scores were calculated. Fasting blood samples were analysed for insulin, glucose, lipid profile and fatty acid (FA) levels (expressed as % total FA). Insulin resistance was estimated by homeostatic model assessment (HOMA). Results: Compared with normal-weight children, obese children exhibited lower mean plasma total PUFA (37.8% vs 39.7%), omega-6 PUFAs (35.0% vs 36.8%) and C22:6omega-3-to-C18:3omega-3 ratio (5.52 vs 7.61), and higher total monounsaturated FA (26.6% vs 25.0%), C18:3omega-3 (0.28% vs 0.25%) and C20:5omega-3 (0.45% vs 0.39%). In obese children, the BMI z-score was negatively related to plasma PUFA, omega-3 PUFAs, C22:6omega-3, and the C22:6omega-3-to-C20:6omega-6 and C22:6omega-3-to-C18:3omega-3 ratios, and positively with total saturated FA and C20:3omega-9.Conclusion: In obese children, plasma LC-PUFA profile may be associated with the degree of obesity.

PMID: 16882570 [PubMed - in process]
Acta Paediatr. 2006 Aug;95(8):964-9.

Fonte: www.pubmed.com

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