(01-02-14) Effects of gastrointestinal motility on obesity

Xiao-Yi Fu, Ze Li, Na Zhang, Hai-Tao Yu, Shu-Ran Wang and Jia-Ren Liu

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Abstract (provisional)
Background

Changes of gastrointestinal motility, which are important related to the
food digestion and absorption in the gastrointestinal tract, may be one of
the factors in obesity-formation.
Aims

The changes of gastrointestinal motility were explored in the rats from
diet-induced obesity (DIO), diet-induced obese resistant (DR) or control
(CON) by diet intervention.
Methods

After fed with a high fat diet (HFD), 100 male Sprague-Dawley rats were
divided into DIO, DR and CON groups. The rats from DIO and DR groups were
fed with HFD, and CON with a normal diet (ND) for 6 weeks. Body weight,
energy intake, gastric emptying, intestinal transit, motility of isolated
small intestine segments and colon's function were measured in this study.
Expression of interstitial cells of Cajal (ICCs) and enteric nervous system
(ENS) - choline acetyltransferase (ChAT), vasoactive intestinal peptides
(VIP), substance P (SP) and NADPH-d histochemistry of nitric oxide synthase
(NOS) were determined by immunohistochemistry.
Results

Body weight and intake energy in the DIO group were higher than those in the
DR group (p < 0.05). Gastric emptying of DIO group rats (78.33 +/- 4.95%)
was significantly faster than that of DR group (51.79 +/- 10.72%) (p <
0.01). The peak value of motility in rat's duodenum from the DR group was
significantly higher than that in the DIO group (p < 0.05). In addition, the
expression of interstitial cells of Cajal (ICC), choline acetyltransferase
(ChAT), substance P (SP), vasoactive intestinal peptides (VIP) and neuronal
nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) in the
intestine of rats were significantly increased in the DIO group when
compared to the DR group (p < 0.05).
Conclusion

A faster gastric emptying, a weaker contraction of duodenum movement, and a
stronger contraction and relaxation of ileum movement were found in the rats
from the DIO group. It indicated that there has effect of gastrointestinal
motility on obesity induced by HFD.


---Source: Nutrition & Metabolism 2014, 11:3 doi:10.1186/1743-7075-11-3
Published: 7 January 2014

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