Seguici su acebook facebook Cerca nel sito:

Le ricerche di Gerona 2005

(05-11-14) Hemoglobin A1c and the Progression of Coronary Artery Calcification Among Adults Without Diabetes.



Carson AP1, Steffes MW2, Carr JJ3, Kim Y4, Gross MD2, Carnethon MR5, Reis JP6, Loria CM6, Jacobs DR Jr7, Lewis CE4.
Author information
Abstract
OBJECTIVE:
Higher levels of hemoglobin A1c (HbA1c) are associated with increased cardiovascular disease risk among individuals without diabetes and may also be positively associated with coronary artery calcification (CAC). This study investigated the association of HbA1c with CAC progression in the Coronary Artery Risk Development in Young Adults study.
RESEARCH DESIGN AND METHODS:
We included 2,076 participants with HbA1c and noncontrast computed tomography (CT) assessed at baseline (2005-2006), and CT repeated 5 years later (2010-2011). CAC progression was defined as 1) incident CAC (increase >0 Agatston units among those with no CAC at baseline), 2) any CAC progression (increase >10 Agatston units between examinations), and 3) advanced CAC progression (increase >100 Agatston units between examinations).
RESULTS:
During the 5-year follow-up period, 12.9% of participants without baseline CAC developed incident CAC; among all participants, 18.2% had any CAC progression and 5.4% had advanced CAC progression. Higher HbA1c was associated with incident CAC (risk ratio [RR] = 1.45; 95% CI 1.02, 2.06), any CAC progression (RR = 1.51; 95% CI 1.16, 1.96), and advanced CAC progression (RR = 2.42; 95% CI 1.47, 3.99) after adjustment for sociodemographic factors. Additional adjustment for cardiovascular risk factors attenuated the associations of HbA1c with incident CAC (RR = 1.05; 95% CI 0.74, 1.49) and any CAC progression (RR = 1.13; 95% CI 0.87, 1.47). In contrast, the association of HbA1c with advanced CAC progression persisted in multivariable adjusted models (RR = 1.78; 95% CI 1.08, 2.95).
CONCLUSIONS:
Higher HbA1c was independently associated with advanced CAC progression among individuals without diabetes, while the associations with incident CAC and any CAC progression were accounted for by other established cardiovascular risk factors.


Source: Diabetes Care. 2014 Oct 16. pii: DC_140360. [Epub ahead of print]

News

  • (30-08-2018) The electronics in fluorescent bulbs and light emitting diodes (LED), rather than ultraviolet radiation, cause increased malignant melanoma incidence in indoor office workers and tanning bed users

    Leggi tutto

  • (30-08-2018) Mitocondri e peso forma

    Leggi tutto

  • (29-08-2018) Stroke now impacting younger patients as a result of the obesity epidemic; 4 in 10 are now aged 40-69

    Leggi tutto

  • (29-08-2018) Perdere peso non vuol dire perdere osso!

    Leggi tutto

  • (29-08-2018) Brain cholesterol: long secret life behind a barrier.

    Leggi tutto

  • (29-08-2018) Stile di vita sano? Si può, basta usare la fantasia

    Leggi tutto

  • (22-08-2018) Top 10 medical treatments that can make you SICKER than before you took them

    Leggi tutto

  • (22-08-2018) Meno ansia - C’è una associazione tra dieta e disturbi mentali?

    Leggi tutto

  • (22-08-2018) Dietary curcumin supplementation attenuates inflammation, hepatic injury and oxidative damage in a rat model of intra-uterine growth retardation.

    Leggi tutto

  • (22-08-2018) Dopo la gravidanza - Una dieta a basso indice glicemico se serve perdere peso

    Leggi tutto

  • (21-08-2018) Sleep Disturbances Can Be Prospectively Observed in Patients with an Inactive Inflammatory Bowel Disease.

    Leggi tutto

  • (21-08-2018) Anche i neo-papà soffrono della depressione post partum

    Leggi tutto

In evidenza

"L'informazione presente nel sito serve a migliorare, e non a sostituire, il rapporto medico-paziente."

Per coloro che hanno problemi di salute si consiglia di consultare sempre il proprio medico curante.

Informazioni utili