(12-12-14) Chronic consumption of trans fat can facilitate the development of hyperactive behavior in rats.

Pase CS1, Roversi K2, Trevizol F1, Kuhn FT1, Dias VT2, Roversi K1, Vey LT3, Antoniazzi CT1, Barcelos R1, Bürger ME4.
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Abstract

In recent decades, the increased consumption of processed foods, which are rich in hydrogenated vegetable fat (HVF), has led to a decreased consumption of fish and oilseed, rich in omega-3 fatty acids. This eating habit provides an increased intake of trans fatty acids (TFA), which may be related to neuropsychiatric conditions, including inattention and hyperactivity. In this study, we evaluated the potential connection between prolonged trans fat consumption and development of hyperactivity-like symptoms in rats using different behavioral paradigms. Trans fat intake for 10months (Experiment 1), as well as during pregnancy and lactation across two sequential generations of rats, (Experiment 4) induced active coping in the forced swimming task (FST). In addition, HVF supplementation was associated with increased locomotion before and after amphetamine (AMPH) administration (Experiment 2). Similarly, HVF supplementation during pregnancy and lactation were associated with increased locomotion in both young and adult rats (Experiment 3). Furthermore, trans fat intake across two sequential generations increased locomotor and exploratory activities following stressors (Experiment 4). From these results, we suggest that chronic consumption of trans fat is able to enhance impulsiveness and reactivity to novelty, facilitating hyperactive behaviors.

Source: Physiol Behav. 2014 Nov 26. pii: S0031-9384(14)00592-7. doi: 10.1016/j.physbeh.2014.11.059. [Epub ahead of print]

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