(15-12-14) Associations between the dietary intake of antioxidant nutrients and the risk of hip fracture in elderly Chinese: a case-control st

Sun LL1, Li BL2, Xie HL1, Fan F1, Yu WZ2, Wu BH1, Xue WQ1, Chen YM1.
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Abstract

The role of oxidative stress in skeletal health is unclear. The present study investigated whether a high dietary intake of antioxidant nutrients (vitamins C and E, β-carotene, animal-derived vitamin A, retinol equivalents, Zn and Se) is associated with a reduced risk of hip fracture in elderly Chinese. This 1:1 matched case-control study involved 726 elderly Chinese with hip fracture and 726 control subjects, recruited between June 2009 and May 2013. Face-to-face interviews were conducted to determine habitual dietary intakes of the above-mentioned seven nutrients based on a seventy-nine-item FFQ and information on various covariates, and an antioxidant score was calculated. After adjustment for potential covariates, dose-dependent inverse associations were observed between the dietary intake of vitamin C, vitamin E, β-carotene, and Se and antioxidant score and the risk of hip fracture (P for trend ≤ 0•005). The OR of hip fracture for the highest (v. lowest) quartile of intake were 0•39 (95 % CI 0•28, 0•56) for vitamin C, 0•23 (95 % CI 0•16, 0•33) for vitamin E, 0•51 (95 % CI 0•36, 0•73) for β-carotene, 0•43 (95 % CI 0•26, 0•70) for Se and 0•24 (95 % CI 0•17, 0•36) for the antioxidant score. A moderate-to-high dietary intake of retinol equivalents in quartiles 2-4 (v. 1) was found to be associated with a lower risk of hip fracture (OR range: 0•51-0•63, P< 0•05). No significant association was observed between dietary Zn or animal-derived vitamin A intake and hip fracture risk (P for trend >0•20). In conclusion, a higher dietary intake of vitamins C and E, β-carotene, and Se and a moderate-to-high dietary intake of retinol equivalents are associated with a lower risk of hip fracture in elderly Chinese.

Source: Br J Nutr. 2014 Nov;112(10):1706-14. doi: 10.1017/S0007114514002773. Epub 2014 Oct 7.

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