(29-01-15) Inflammation and vitamin D: the infection connection

Meg Mangin • Rebecca Sinha • Kelly Fincher

Abstract
Introduction Inflammation is believed to be a contributing
factor to many chronic diseases. The influence of
vitamin D deficiency on inflammation is being explored but
studies have not demonstrated a causative effect.
Methods Lowserum 25(OH)Dis also found in healthy persons
exposed to adequate sunlight. Despite increased vitamin D supplementation
inflammatory diseases are increasing. The current
method of determining vitaminDstatusmaybe at fault. The level
of 25(OH)D does not always reflect the level of 1,25(OH)2D.
Assessment of both metabolites often reveals elevated
1,25(OH)2D, indicating abnormal vitaminDendocrine function.
Findings This article reviews vitamin D’s influence on the
immune system, examines the myths regarding vitamin D
photosynthesis, discusses ways to accurately assess vitamin
D status, describes the risks of supplementation, explains the
effect of persistent infection on vitamin D metabolism and
presents a novel immunotherapy which provides evidence of
an infection connection to inflammation.
Conclusion Some authorities now believe that low 25(OH)D
is a consequence of chronic inflammation rather than the cause.
Research points to a bacterial etiology pathogenesis for an
inflammatory disease process which results in high 1,25(OH)2D
and low 25(OH)D. Immunotherapy, directed at eradicating
persistent intracellular pathogens, corrects dysregulated vitamin
D metabolism and resolves inflammatory symptoms.

Source: Inflamm. Res.
DOI 10.1007/s00011-014-0755-z
Received: 1 November 2013 / Revised: 4 June 2014 / Accepted: 23 June 2014
The Author(s) 2014. This article is published with open access at Springerlink.com

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