(09-02-15) Nutrient regulation of glucagon secretion: involvement in metabolism and diabetes.

Authors
Marroquí L1, Alonso-Magdalena P1, Merino B1, Fuentes E1, Nadal A1,Quesada I1.
Author information
Journal
Nutr Res Rev. 2014 Jun;27(1):48-62. doi: 10.1017/S0954422414000031. Epub 2014 Apr 10.
Affiliation
Abstract
Glucose homeostasis is precisely regulated by glucagon and insulin, which are released by pancreatic α- and β-cells, respectively. While β-cells have been the focus of intense research, less is known about α-cell function and the actions of glucagon. In recent years, the study of this endocrine cell type has experienced a renewed drive. The present review contains a summary of established concepts as well as new information about the regulation of α-cells by glucose, amino acids, fatty acids and other nutrients, focusing especially on glucagon release, glucagon synthesis and α-cell survival. We have also discussed the role of glucagon in glucose homeostasis and in energy and lipid metabolism as well as its potential as a modulator of food intake and body weight. In addition to the well-established action on the liver, we discuss the effects of glucagon in other organs, where the glucagon receptor is expressed. These tissues include the heart, kidneys, adipose tissue, brain, small intestine and the gustatory epithelium. Alterations in α-cell function and abnormal glucagon concentrations are present in diabetes and are thought to aggravate the hyperglycaemic state of diabetic patients. In this respect, several experimental approaches in diabetic models have shown important beneficial results in improving hyperglycaemia after the modulation of glucagon secretion or action. Moreover, glucagon receptor agonism has also been used as a therapeutic strategy to treat obesity.

Source:
Nutr Res Rev. 2014 Jun;27(1):48-62. doi: 10.1017/S0954422414000031. Epub 2014 Apr 10.

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