(02-05-15) Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease.

Wang J1, Lv S2, Chen G3, Gao C4, He J5, Zhong H6, Xu Y7.
Author information
1Department of Endocrinology and Metabolism, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China. [email protected].
2Department of Endocrinology and Metabolism, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China. [email protected].
3Department of Endocrinology and Metabolism, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China. [email protected].
4Department of Endocrinology and Metabolism, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China. [email protected].
5Department of Endocrinology and Metabolism, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China. [email protected].
6Department of Endocrinology and Metabolism, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China. [email protected].
7Department of Endocrinology and Metabolism, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China. [email protected].
Abstract
Although emerging evidence suggests that low levels of vitamin D may contribute to the development of autoimmune disease, the relationship between vitamin D reduction and autoimmune thyroid disease (AITD), which includes Graves' disease (GD) and Hashimoto thyroiditis (HT), is still controversial. The aim was to evaluate the association between vitamin D levels and AITD through systematic literature review. We identified all studies that assessed the association between vitamin D and AITD from PubMed, Embase, CENTRAL, and China National Knowledge Infrastructure (CNKI) databases. We included studies that compared vitamin D levels between AITD cases and controls as well as those that measured the odds of vitamin D deficiency by AITD status. We combined the standardized mean differences (SMD) or the odds ratios (OR) in a random effects model. Twenty case-control studies provided data for a quantitative meta-analysis. Compared to controls, AITD patients had lower levels of 25(OH)D (SMD: -0.99, 95% CI: -1.31, -0.66) and were more likely to be deficient in 25(OH)D (OR 2.99, 95% CI: 1.88, 4.74). Furthermore, subgroup analyses result showed that GD and HT patients also had lower 25(OH)D levels and were more likely to have a 25(OH)D deficiency, suggesting that low levels of serum 25(OH)D was related to AITD.

SOURCE: Nutrients. 2015 Apr 3;7(4):2485-2498.

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