(09-07-15) Thyroid Autoimmunity in the Context of Type 2 Diabetes Mellitus: Implications for Vitamin D.

Toulis K1, Tsekmekidou X1, Potolidis E1, Didangelos T2, Gotzamani-Psarrakou A3, Zebekakis P1, Daniilidis M4, Yovos J1, Kotsa K1.
Author information
1Diabetes Center, Department of Endocrinology and Metabolism, AHEPA University Hospital, 54636 Thessaloniki, Greece.
2First Propaedeutic Department of Internal Medicine, AHEPA University Hospital, 54636 Thessaloniki, Greece.
3Laboratory of Nuclear Medicine, AHEPA University Hospital, 54636 Thessaloniki, Greece.
4First Department of Medicine, AHEPA University Hospital, 54636 Thessaloniki, Greece.
Abstract
Vitamin D deficiency has been associated with both type 2 diabetes mellitus (T2DM) and autoimmune disorders. The association of vitamin D with T2DM and thyroid autoimmunity (TAI) has not been investigated. Thus, we aimed to explore the putative association between T2DM and thyroid autoimmunity (TAI) focusing on the role of 25-hydroxy-vitamin D (25(OH)D). Study population included 264 T2DM patients and 234 controls. To explore the potential association between 25(OH)D and thyroid autoimmunity while controlling for potential confounders-namely, age, gender, body mass index, and presence of T2DM-multivariate logistic regression analyses were undertaken. Patients with T2DM were younger (P < 0.001) and had significantly lower 25(OH)D levels (P < 0.001) and higher anti-TPO titers (P = 0.005). Multivariable logistic regression analyses suggested that T2DM and 25(OH)D levels were significantly associated with the presence of thyroid autoimmunity. In an elderly population of diabetic patients and controls with a high prevalence of vitamin D deficiency/insufficiency, a patient with T2DM was found to be 2.5 times more likely to have thyroid autoimmunity compared to a nondiabetic individual and the higher the serum 25(OH)D levels were, the higher this chance was.

Source: Int J Endocrinol. 2015;2015:710363. doi: 10.1155/2015/710363. Epub 2015 May 19.

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