(31-07-15) Endothelial progenitor cell senescence is there a role for estrogen?

1. Toshio Imanishi
1. Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan, [email protected]
1. Hiroto Tsujioka
1. Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
1. Takashi Akasaka
1. Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan
Abstract
Recent studies have demonstrated that aging or senescence constitutes a potential limitation to the ability of endothelial progenitor cells (EPCs) to sustain ischemic tissue repair. Excess amount of reactive oxygen species (ROS) is involved in senescence, causing defective neovascularization. Conversely, estrogens have been shown to accelerate recovery of the endothelium after vascular injury. Estrogen reduces EPC senescence through augmentation of telomerase activity. In addition, the inhibition of EPC senescence by estrogen in vitro may improve the functional activity of EPCs in a way that is important for potential cell therapy. This review describes current understanding of EPC senescence and the role of estrogen in preventing EPC senescence.

SOURCE: http://tak.sagepub.com/content/4/1/55.abstract

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