(15-10-15) Depression and extremes of blood pressure predict highest rates of harmful vascular events

as presented at the annual meeting of the European Society of Cardiology
Depressive symptoms and extremes of blood pressure predict the highest rates of harmful vascular events in patients with existing heart disease, diabetes, or stroke, according to the results of a large study presented at ESC, held in August-September in London.
The research found that the risk of further stroke or heart attack, heart failure, or dying due to heart disease after four years was 83% higher in depressed patients with high BP and 36% higher in depressed patients with low BP, compared to those with normal blood pressure and no depressive symptoms. 
The study included 35,537 community dwelling patients in Scotland with existing heart disease, diabetes, or stroke.  The occurrence of major harmful events (further stroke or heart attack, heart failure, or dying due to heart disease) was recorded over the four-year period. In that time 3939 patients (11%) had a least one major harmful event. Depression had a significant interaction with systolic blood pressure (SBP) in predicting a major harmful event (P=0.03). 
Patients with the combination of high blood pressure and depressive symptoms had an 83% higher risk of a major harmful event at four years (hazard ratio [HR] 1.83; P <0.001) and those with low blood pressure and depressive symptoms had a 36% higher risk (HR 1.36; P <0.001) than those with normal blood pressure and no depressive symptoms. The results were adjusted for factors that can influence risk of vascular events such as age, sex, body mass index (BMI), total cholesterol, socioeconomic status, use of antidepressants, and number of existing medical conditions.

Source: quotivadis.it

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