(07-11-15) Vitamin D supplementation may have beneficial effect on pregnancy outcomes

as presented at the annual meeting of the American Society for Reproductive Medicine
New data point to a possible association between increases in vitamin D concentrations and both increases in live birth and decreases in pregnancy loss.  The results were released at ASRM in October in Baltimore, Maryland.
Dr. Sunni L. Mumford, with the National Institutes of Health in Rockville, Maryland, and colleagues elsewhere assessed the relationship between vitamin D and pregnancy loss and live birth rates among women with proven fecundity in a secondary analysis of the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial. 
The multicenter EAGeR trial evaluated the effect of preconception-initiated daily low-dose aspirin on reproductive outcomes in women with a history of pregnancy loss.  Participants were attempting pregnancy, aged 18-40 years, with one to two prior pregnancy losses and no history of infertility or other gynecologic disorders.
Live birth was defined as a living infant born after 23 weeks’ gestation.  Pregnancy status was determined using daily first-morning urine collection and spot urine clinic pregnancy tests at monthly visits.  Chemical pregnancy loss was defined as positive hCG without clinical evidence of pregnancy (n=56), and clinical pregnancy loss as a loss following ultrasound-confirmed pregnancy (n=133).
Seventeen women (2%) had deficient vitamin D levels at baseline (<30 nmol/L), and 148 (12%) women had inadequate levels (30-49 nmol/L).  Overall, vitamin D levels were positively associated with live birth (RR 1.03, 95% CI 1.01, 1.05 per 10 nmol/L).  Vitamin D levels were also inversely associated with pregnancy loss (RR 0.95, 95% CI 0.91, 1.00 per 10 nmol/L) and specifically clinical loss (RR 0.94, 95% CI 0.88, 1.00 per 10 nmol/L).
Dr. Mumford pointed out that prior research has shown that Vitamin D supplementation is associated with reduced rates of pregnancy complications but the data have been mixed.  Results from the secondary analysis of the EAGeR trial highlight the potential beneficial role of vitamin D on pregnancy outcomes, she said.

Fonte: quotivadis.it

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