(10-11-15) Effects of zeolite supplementation on parameters of intestinal barrier integrity, inflammation, redoxbiology and performance

Effects of zeolite supplementation on parameters of intestinal barrier integrity, inflammation, redoxbiology and performance in aerobically trained subjects

Manfred Lamprecht12*, Simon Bogner2, Kurt Steinbauer3, Burkhard Schuetz4, Joachim F. Greilberger15, Bettina Leber6, Bernhard Wagner7, Erwin Zinser7, Thomas Petek8, Sandra Wallner-Liebmann9, Tanja Oberwinkler10,Norbert Bachl11 and Gert Schippinger3

Abstract
Background
Zeolites are crystalline compounds with microporous structures of Si-tetrahedrons. In the gut, these silicates could act as adsorbents, ion-exchangers, catalysts, detergents or anti-diarrheic agents. This study evaluated whether zeolite supplementation affects biomarkers of intestinal wall permeability and parameters of oxidation and inflammation in aerobically trained individuals, and whether it could improve their performance.
Methods
In a randomized, double-blinded, placebo controlled trial, 52 endurance trained men and women, similar in body fat, non-smokers, 20–50 years, received 1.85 g of zeolite per day for 12 weeks. Stool samples for determination of intestinal wall integrity biomarkers were collected. From blood, markers of redox biology, inflammation, and DNA damage were determined at the beginning and the end of the study. In addition, VO 2max and maximum performance were evaluated at baseline and after 12 weeks of treatment. For statistical analyses a 2-factor ANOVA was used.
Results
At baseline both groups showed slightly increased stool zonulin concentrations above normal. After 12 weeks with zeolite zonulin was significantly (p < 0.05) decreased in the supplemented group. IL-10 increased tendentially (p < 0.1) in the zeolite group. There were no significant changes observed in the other measured parameters.
Conclusions
Twelve weeks of zeolite supplementation exerted beneficial effects on intestinal wall integrity as indicated via decreased concentrations of the tight junction modulator zonulin. This was accompanied by mild anti-inflammatory effects in this cohort of aerobically trained subjects. Further research is needed to explore mechanistic explanations for the observations in this study.


Source: Journal of the International Society of Sports Nutrition 2015, 12:40  doi:10.1186/s12970-015-0101-z
Published: 20 October 2015

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