(29-11-15) Short-term abstinence from alcohol improves insulin resistance and risk factors for nonalcoholic fatty liver disease | AASLD

1. RSi Communications
2. 17 Nov 2015
3. 74 Visualizzazioni
4. 3 Stelle

5. as presented at the annual meeting of the American Academy for the Study of Liver Disease
Short-term abstinence from drinking improves insulin resistance and risk factors for nonalcoholic fatty liver disease (NAFLD) in moderate drinkers, according to a study presented at AASLD, held in November in San Francisco.
Alcoholic (ALD) and non-alcoholic (NAFLD) fatty liver disease are among the commonest causes of cirrhosis worldwide. Several parallels between ALD and NAFLD exist, with 35%-60% of ALD patients having metabolic syndrome and increased risk of NAFLD independent of alcohol consumption. Researchers at the UCL Institute of Liver and Digestive Health in London designed a study to determine the effect of one-month abstinence on insulin resistance and other markers of NAFLD in moderate drinkers, taking advantage of the “Dry January” campaign in the U.K.
One hundred and two participants in the campaign were recruited (48 male, 56 female, mean age 45.9). Their mean alcohol intake was 251.6 g/week (men 270.8, women 234.8). Significant reductions (pre vs post) were found in HOMA-IR score: 1.57 IU vs 1.13 IU, P <0.001; liver stiffness 4.79 kPa vs 4.19 kPa, P<0.05; systolic blood pressure 134.8 mmHg vs 127.2 mmHg, P <0.0001; and BMI 26.8 kg/m2 vs 26.1 kg/m2, P <0.05. These findings remained significant following modeling for demographic and lifestyle factors including age, gender, changes in diet, exercise, smoking, and stress. No significant change was found in CAP score, 244.3 dB/m vs 242.5 dB/m.
“This is a novel association between alcohol consumption and insulin resistance in healthy individuals,” the study authors concluded, “although prior studies have documented an association between insulin resistance and portal hypertension.”

Source:
http://www.univadis.it/conference-reports/10/Short-term-abstinence-from-alcohol-improves-insulin-resistance-and-risk-factors-for-nonalcoholic-fatty-liver-disease-AASLD?utm_source=newsletter+email&utm_medium=email&utm_campaign=medical+updates+-+daily&utm_content=475916&utm_term=automated_daily

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