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(12-12-15) Effect of Dietary Supplementation with Omega-3 Fatty Acid and gamma-linolenic Acid on Acne Vulgaris


Effect of Dietary Supplementation with Omega-3 Fatty Acid and gamma-linolenic Acid on Acne Vulgaris: A Randomised, Double-blind, Controlled Trial

Jae Yoon Jung1,2,4, Hyuck Hoon Kwon1,2, Jong Soo Hong1, Ji Young Yoon2, Mi Sun Park3, Mi Young Jang3 and Dae Hun Suh1,2

1Department of Dermatology, Seoul National University College of Medicine, 2Acne and Rosacea Research Laboratory, 3Department of Food Service and Nutrition Care, Seoul National University Hospital, and 4Oracle Dermatology Clinic, Seoul, Korea


This study was undertaken to evaluate the clinical efficacy, safety, and histological changes induced by dietary omega-3 fatty acid and ã-linoleic acid in acne vulgaris. A 10-week, randomised, controlled parallel dietary intervention study was performed in 45 participants with mild to moderate acne, which were allocated to either an omega-3 fatty acid group (2,000 mg of eicosapentaenoic acid and docosahexaenoic acid), a ã-linoleic acid group (borage oil containing 400 mg ã-linoleic acid), or a control group. After 10 weeks of omega-3 fatty acid or ã-linoleic acid supplementation, inflammatory and non-inflammatory acne lesions decreased significantly. Patient subjective assessment of improvement showed a similar result. Heamatoxylin & eosin staining of acne lesions demonstrated reductions in inflammation and immunohistochemical staining intensity for interleukin-8. No severe adverse effect was reported. This study shows for the first time that omega-3 fatty acid and ã-linoleic acid could be used as adjuvant treatments for acne patients. Key words: acne; ã-linoleic acid; omega-3 fatty acid.

Accepted Jan 8, 2014; Epub ahead of print Feb 18, 2014
The authors declare no conflict of interest.


Source: http://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-1802

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