(19-12-15) Increased Cardiovascular Mortality in Subjects With Metabolic Syndrome Is Largely Attributable to Diabetes and Hypertension

Increased Cardiovascular Mortality in Subjects With Metabolic Syndrome Is Largely Attributable to Diabetes and Hypertension in 159,971 Korean Adults.
Sung KC1, Rhee EJ1, Ryu S1, Kim BJ1, Kim BS1, Lee WY1, Oh KW1, Kim YB1, Chung PW1, Kim H1, Byrne CD1, Lee KB1, Park SW1.
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Abstract
CONTEXT:
Metabolic syndrome (MetS) is a risk factor for cardiovascular disease (CVD) mortality.
OBJECTIVE:
This study aimed to evaluate the association of MetS with all-cause and cardiovascular mortality in apparently healthy young Korean subjects.
DESIGN:
A retrospective study of 155,971 participants (mean age, 41.8 y) in a health screening program, followed up for 3.7 years (597,628.2 person-years). The risk for all-cause mortality and CVD mortality were analyzed according to the presence or absence of MetS.
MAIN OUTCOMES:
A total of 542 subjects died during followup. Women with MetS showed a significantly increased age-adjusted hazard ratio (HR) for all-cause mortality compared with women without MetS, even after adjustment for confounding factors (HR, 1.82; 95% confidence interval [CI], 1.15-2.88). Subjects with MetS showed a significantly increased risk for CVD mortality compared with those without MetS, even after adjustment for confounding factors (HR, 1.60; 95% CI, 1.02-2.20), of which significance disappeared when subjects with diabetes or hypertension at baseline were excluded from the analysis (HR, 0.95; 95% CI, 0.29-3.12).
CONCLUSIONS:
The presence of MetS increased the risk for all-cause mortality in women and the risk for CVD mortality in total population. These increased HR attributed to the pre-existing diabetes or hypertension in this population.

Source:
J Clin Endocrinol Metab. 2015 Jul;100(7):2606-12. doi: 10.1210/jc.2014-4031. Epub 2015 May 20.

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