(03-04-16) Discovery of plant extracts that greatly delay yeast chronological aging and have different effects on longevity-defining cellular

(03-04-16) Discovery of plant extracts that greatly delay yeast chronological aging and have different effects on longevity-defining cellular processes.

Lutchman V1, Medkour Y1, Samson E1, Arlia-Ciommo A1, Dakik P1, Cortes B1, Feldman R1, Mohtashami S1, McAuley M1, Chancharoen M1, Rukundo B1, Simard É2, Titorenko VI1.
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Abstract
We discovered six plant extracts that increase yeast chronological lifespan to a significantly greater extent than any of the presently known longevity-extending chemical compounds. One of these extracts is the most potent longevity-extending pharmacological intervention yet described. We show that each of the six plant extracts is a geroprotector which delays the onset and decreases the rate of yeast chronological aging by eliciting a hormetic stress response. We also show that each of these extracts has different effects on cellular processes that define longevity in organisms across phyla. These effects include the following: 1) increased mitochondrial respiration and membrane potential; 2) augmented or reduced concentrations of reactive oxygen species; 3) decreased oxidative damage to cellular proteins, membrane lipids, and mitochondrial and nuclear genomes; 4) enhanced cell resistance to oxidative and thermal stresses; and 5) accelerated degradation of neutral lipids deposited in lipid droplets. Our findings provide new insights into mechanisms through which chemicals extracted from certain plants can slow biological aging.


Source: Oncotarget. 2016 Feb 24. doi: 10.18632/oncotarget.7665. [Epub ahead of print]

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