(01-07-16) Meta-analysis and meta-regression of omega-3 polyunsaturated fatty acid supplementation for major depressive disorder

R J T Mocking1, I Harmsen1, J Assies1, M W J Koeter1, H G Ruhé1,2,5 and A H Schene3,4,5

Omega-3 polyunsaturated fatty acid (PUFA) supplementation has been proposed as (adjuvant) treatment for major depressive disorder (MDD). In the present meta-analysis, we pooled randomized placebo-controlled trials assessing the effects of omega-3 PUFA supplementation on depressive symptoms in MDD. Moreover, we performed meta-regression to test whether supplementation effects depended on eicosapentaenoic acid (EPA) or docosahexaenoic acid dose, their ratio, study duration, participants’ age, percentage antidepressant users, baseline MDD symptom severity, publication year and study quality. To limit heterogeneity, we only included studies in adult patients with MDD assessed using standardized clinical interviews, and excluded studies that specifically studied perinatal/perimenopausal or comorbid MDD. Our PubMED/EMBASE search resulted in 1955 articles, from which we included 13 studies providing 1233 participants. After taking potential publication bias into account, meta-analysis showed an overall beneficial effect of omega-3 PUFAs on depressive symptoms in MDD (standardized mean difference=0.398 (0.114–0.682), P=0.006, random-effects model). As an explanation for significant heterogeneity (I

Fonte:
http://www.nature.com/tp/journal/v6/n3/full/tp201629a.html
Citation: Translational Psychiatry (2016) 6, e756; doi:10.1038/tp.2016.29
Published online 15 March 2016

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