(13-12-06) Serum adiponectin is a predictor of coronary heart disease:

a population-based 10-year follow-up study in elderly men.

Frystyk J,Berne C, Berglund L, Jensevik K, Flyvbjerg A, Zethelius B.


The Medical Research Laboratories, Clinical Institute, Aarhus University Hospital (JF, AF), Denmark; Departments of Medical Sciences (CB) and Public Health and Caring Sciences/Geriatrics (BZ), Uppsala University, Sweden and Uppsala Clinical Research Centre (KJ, LB), Uppsala, Sweden.
Context: Cross-sectional and nested case-control studies indicate a relationship between adiponectin, obesity and coronary heart disease (CHD). Objective: To investigate whether adiponectin could predict CHD in a population-based cohort of elderly men. Design and Setting: In 1991 to 1995 a baseline investigation was carried out in 832 healthy men aged 70 in the Uppsala Longitudinal Study of Adult Men (ULSAM study). They were followed up to 10.4 yr using Swedish national registry data. The baseline investigation included anthropometry, blood pressure (BP), smoking, serum lipids, an euglycemic insulin clamp and fasting serum adiponectin. Main Outcome Measures: Defined as death or first time hospitalization for CHD (n = 116), recorded in the Cause of Death Registry or in the Hospital-Discharge Registry of the National Board of Health and Welfare, Sweden. Associations were analyzed using Cox's proportional hazards regression, presented as hazard ratios (HRs) with 95% confidence intervals (CIs) for one SD increase in the predictor variable. Results: In a multivariable analysis including total cholesterol (HR 1.24; CI 1.02-1.50), high density lipoprotein cholesterol (HR 0.72; CI 0.58-0.89), smoking (HR 1.39; CI 0.91-2.14) and systolic BP (HR 1.26; CI 1.05-1.52) serum adiponectin was associated with lower risk for CHD (HR 0.81; CI 0.66-0.99). The association was independent of BMI and remained significant after adjustment for insulin sensitivity index. Conclusions: In this population-based cohort of healthy men, elevated serum levels of adiponectin was associated with a lower risk for CHD. Importantly, the association between adiponectin and CHD was independent of other well-known risk factors.

Source: J Clin Endicrinol Metab

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