(26-04-2017) A very low-fat diet is not associated with improved lipoprotein profiles in men with a predominance of large, low-density lipoprot

Dreon DM1, Fernstrom HA, Williams PT, Krauss RM.
Author information

1
Donner Laboratory, Lawrence Berkeley National Laboratory, University of California, Berkeley 94720, USA.
Abstract

BACKGROUND:

We found previously that men with a predominance of large LDL particles (phenotype A) consuming high-fat diets (40-46% fat) show less lipoprotein benefits of low-fat diets (20-24% fat) than do men with a high-risk lipoprotein profile characterized by a predominance of small LDL (phenotype B). Furthermore, one-third of men with phenotype A consuming a high-fat diet converted to phenotype B with a low-fat diet.

OBJECTIVE:

We investigated effects of further reduction in dietary fat in men with persistence of LDL subclass phenotype A during both high- and low-fat diets.

DESIGN:

Thirty-eight men who had shown phenotype A after 4-6 wk of both high- and low-fat diets consumed for 10 d a 10%-fat diet (2.7% saturates) with replacement of fat with carbohydrate and no change in cholesterol content or ratio of polyunsaturates to saturates.

RESULTS:

In 26 men, phenotype A persisted (stable A group) whereas 12 converted to phenotype B (change group). LDL cholesterol did not differ from previous values for 20-24%-fat diets in either group, whereas in the change group there were higher concentrations of triacylglycerol and apolipoprotein B; greater mass of HDL, large LDL-I, small LDL-III and LDL-IV, and HDL3; lower concentrations of HDL cholesterol, apolipoprotein A-I; and lower mass of large LDL-I and HDL2.

CONCLUSIONS:

There is no apparent lipoprotein benefit of reduction in dietary fat from 20-24% to 10% in men with large LDL particles: LDL-cholesterol concentration was not reduced, and in a subset of subjects there was a shift to small LDL along with increased triacylglycerol and reduced HDL-cholesterol concentrations.

Comment in

Very-low-fat diets do not necessarily promote small, dense LDL particles. [Am J Clin Nutr. 1999]
Low-fat, high-sugar diet and lipoprotein profiles. [Am J Clin Nutr. 1999]

Source: Am J Clin Nutr. 1999 Mar;69(3):411-8.

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