(04-06-2017) Cholesterol and all-cause mortality in elderly people from the Honolulu Heart Program: a cohort study

Prof Dr Irwin J Schatz, MDa, , ,
Prof Kamal Masaki, MDa,
Katsuhiko Yano, MDb,
Randi Chen, MSb,
Prof Beatriz L Rodriguez, MDa,
Prof J David Curb, MDa
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https://doi.org/10.1016/S0140-6736(01)05553-2
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Summary

Background

A generally held belief is that cholesterol concentrations should be kept low to lessen the risk of cardiovascular disease. However, studies of the relation between serum cholesterol and all-cause mortality in elderly people have shown contrasting results. To investigate these discrepancies, we did a longitudinal assessment of changes in both lipid and serum cholesterol concentrations over 20 years, and compared them with mortality.

Methods

Lipid and serum cholesterol concentrations were measured in 3572 Japanese/American men (aged 71–93 years) as part of the Honolulu Heart Program. We compared changes in these concentrations over 20 years with all-cause mortality using three different Cox proportional hazards models.

Findings

Mean cholesterol fell significantly with increasing age. Age-adjusted mortality rates were 68·3, 48·9, 41·1, and 43·3 for the first to fourth quartiles of cholesterol concentrations, respectively. Relative risks for mortality were 0·72 (95% CI 0·60–0·87), 0·60 (0·49–0·74), and 0·65 (0·53–0·80), in the second, third, and fourth quartiles, respectively, with quartile 1 as reference. A Cox proportional hazard model assessed changes in cholesterol concentrations between examinations three and four. Only the group with low cholesterol concentration at both examinations had a significant association with mortality (risk ratio 1·64, 95% CI 1·13–2·36).

Interpretation

We have been unable to explain our results. These data cast doubt on the scientific justification for lowering cholesterol to very low concentrations (<4·65 mmol/L) in elderly people.

Source: The Lancet
Volume 358, Issue 9279, 4 August 2001, Pages 351–355

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