(11-12-2017) Vitamin D Deficiency

Michael F. Holick, M.D., Ph.D.

N Engl J Med 2007; 357:266-281July 19, 2007DOI: 10.1056/NEJMra070553

Once foods in the United States were fortified with vitamin D, rickets
appeared to have been conquered, and many considered major health
problems from vitamin D deficiency resolved. But vitamin D deficiency
is common. This review considers the role of vitamin D in skeletal and
nonskeletal health and suggests strategies for the prevention and
treatment of vitamin D deficiency.

Supported in part by grants from the National Institutes of Health
(M01RR00533 and AR36963) and the UV Foundation.

Dr. Holick reports receiving honoraria from Merck, Eli Lilly, and
Procter & Gamble and consulting fees from Quest Diagnostics, Amgen,
Novartis, and Procter & Gamble. No other potential conflict of
interest relevant to this article was reported.

I thank Dr. Farhad Chimeh for his helpful review of an earlier version
of this manuscript and Donna Gendron and Lorrie MacKay for their
secretarial assistance.

Source Information

From the Department of Medicine, Section of Endocrinology, Nutrition,
and Diabetes, the Vitamin D, Skin, and Bone Research Laboratory,
Boston University Medical Center, Boston.

Address reprint requests to Dr. Holick at Boston University School of
Medicine, 715 Albany St., M-1013, Boston, MA 02118, or at
[email protected].

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