(11-05-2018) Man with a Swollen Eye: Nonspecific Orbital Inflammation in an Adult in the Emergency Department.
Zhang XC 1, Statler B 2, Suner S 3, Lloyd M 2, Curley D 4, Migliori ME 5.
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Abstract
BACKGROUND:
Nonspecific orbital inflammation (NSOI) is a rare idiopathic ocular pathology characterized by unilateral, painful orbital swelling without identifiable infectious or systemic disorders, which can be complicated by optic nerve compromise.
CASE REPORT:
A 50-year-old man presented to the Emergency Department with recurring, progressive painless left eye swelling, decreased visual acuity, and binocular diplopia in the absence of trauma, infection, or known malignancy. His physical examination was notable for left-sided decreased visual acuity, an afferent pupillary defect, severe left eye proptosis and chemosis, and restricted extraocular movements; his dilatated funduscopic examination was notable for ipsilateral retinal folds within the macula, concerning for a disruption between the sclera and the retina. Ocular examination of the right eye was unremarkable. Laboratory data were unrevealing. Gadolinium-enhanced magnetic resonance imaging showed marked thickening of the left extraocular muscles associated with proptosis, dense inflammatory infiltration of the orbital fat, and characteristics consistent with perineuritis. The patient was diagnosed with NSOI with optic neuritis and admitted for systemic steroid therapy; he was discharged on hospital day 2 after receiving high-dose intravenous (i.v.) methylprednisolone with significant improvement. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: NSOI is a rare and idiopathic ocular emergency, with clinical mimicry resembling a broad spectrum of systemic diseases such as malignancy, autoimmune diseases, endocrine disorders, and infection. Initial work-up for new-onset ocular proptosis should include comprehensive laboratory testing and gadolinium-enhanced magnetic resonance imaging. Timely evaluation by an ophthalmologist is crucial to assess for optic nerve involvement. Signs of optic nerve compromise include decreased visual acuity, afferent pupillary defect, or decreased color saturation. Patients with optic nerve compromise require admission for aggressive anti-inflammatory therapy with i.v. steroids in an attempt to reduce risk of long-term visual sequelae. Our case demonstrates a severe presentation of this disorder and exhibits remarkable visual recovery after 48 h of systemic i.v. steroid treatment.
Published by Elsevier Inc.
Commento Dr. Parisi: L'NSOI , considerando che rappresenta un'emergenza oculare rara e idiopatica, con mimetismo clinico che assomiglia a un ampio spettro di malattie sistemiche quali malignità , malattie autoimmuni, disturbi endocrini e infezioni, potrebbe senz' altro essere gestita , in fase acuta con alte dosi di omega 3 e passata la fase acuta anche con un ' approccio alimentare stile Paleozona !!
Source: J Emerg Med. 2018 Apr 28. pii: S0736-4679(18)30339-1. doi: 10.1016/j.jemermed.2018.04.001. [Epub ahead of print]
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