(17-02-07) Vitamin A, retinol, and carotenoids and the risk of gastric cancer: a prospective cohort study1,2,3

Susanna C Larsson, Leif Bergkvist, Ingmar N?slund, J?rgen Ruteg?rd and Alicja Wolk
1 From the Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (SCL and AW); the Department of Surgery and Centre for Clinical Research, Central Hospital, V?ster?s, Sweden (LB); the Department of Surgery, ?rebro University Hospital, ?rebro, Sweden (IN); and the Department of Surgery, Section of Colorectal Surgery, University Hospital, ?rebro, Sweden (JR)
Background: Vitamin A may influence gastric carcinogenesis through its essential role in controlling cell proliferation and differentiation. However, epidemiologic studies of vitamin A, retinol (preformed vitamin A), and provitamin A carotenoids in relation to the risk of gastric cancer have documented inconsistent results.
Objective: The objective of the study was to examine the associations between intakes of vitamin A, retinol, and specific carotenoids and the risk of gastric cancer in a prospective population-based cohort study of Swedish adults.
Design: The study cohort consisted of 82 002 Swedish adults aged 45?83 y who had completed a food-frequency questionnaire in 1997. The participants were followed through June 2005.
Results: During a mean 7.2-y follow-up, 139 incident cases of gastric cancer were diagnosed. High intakes of vitamin A and retinol from foods only (dietary intake) and from foods and supplements combined (total intake) and of dietary -carotene and ?-carotene were associated with a lower risk of gastric cancer. The multivariate relative risks for the highest versus lowest quartiles of intake were 0.53 (95% CI: 0.32, 0.89; P for trend = 0.02) for total vitamin A, 0.56 (95% CI: 0.33, 0.95; P for trend = 0.05) for total retinol, 0.50 (95% CI: 0.30, 0.83; P for trend = 0.03) for -carotene, and 0.55 (95% CI: 0.32, 0.94; P for trend = 0.07) for ?-carotene. No significant associations were found for ?-cryptoxanthin, lutein and zeaxanthin, or lycopene intake.


FONTE: AJCN

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