(18-04-07) Low serum high-density lipoprotein cholesterol in obese subjects with normal serum triglycerides:

the role of insulin resistance.

Mooradian AD, Albert SG, Haas MJ.
Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Saint Louis University School of Medicine, Saint Louis, MO, USA.

Background: The cause of obesity-related low HDLc in the absence of hypertriglyceridemia is not known. Subjects & methods: A total of 32 subjects with a body mass index (BMI)(kg/m(2)) greater than 30 and normal serum triglycerides (<150 mg/dl) were identified. Results: People with low HDLc (n = 16) compared to those with normal HDLc (n = 16) had higher BMI (37.53 +/- 4.54 vs. 33.99 +/- 3.65 kg/m(2), p < 0.021), higher body fat weight (42.59 +/- 9.51 vs. 34.76 +/- 8.7 kg, p < 0.023), and higher insulin resistance index (3.75 +/- 2.51 vs. 1.95 +/- 1.10, p < 0.013). Seven subjects with low HDLc and none of those with normal HDLc, had elevated serum tumor necrosis factor alpha and/or interleukin-6 (p < 0.010). Conclusions: Low HDLc levels can occur in obesity independently of elevated serum triglycerides and may be secondary to elevated serum levels of inflammatory cytokines

Fonte: Diabetes obes Metab

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