(02-05-07) New mechanism for an old drug: aspirin triggers anti-inflammatory lipid mediators with gender implications.

Chiang N, Serhan CN.
The Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Aspirin increases anti-inflammatory aspirin-triggered lipoxin A4 levels in healthy subjects in a gender-specific manner in a randomized clinical study. Thus, formation of aspirin-triggered lipoxin A4 may provide a novel mechanism underlying aspirin's clinical benefits, and shed light on gender-dependent therapeutics of aspirin.

Fonte: Compr Ther.

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