(03-05-07) Effect of fish oil supplementation on Fatty Acid status, coordination

and fine motor skills in children with phenylketonuria.


Beblo S, Reinhardt H, Demmelmair H, Muntau AC, Koletzko B.
Division of Metabolic Diseases and Nutrition, Dr. von Haunersches Kinderspital, Ludwig-Maximilians-University, Munich, Germany.

OBJECTIVE: To investigate effects of long-chain omega-3 polyunsaturated fatty acids (LC-PUFA) on motor skills in patients with phenylketonuria (PKU). STUDY DESIGN: Thirty-six patients with PKU (1-11 years of age, good metabolic control: plasma phenylalanine /=6 months). We determined plasma phospholipid fatty acids, and in patients >4 years of age (N = 24) the motometric Rostock-Oseretzky Scale (ROS), before and after supplementation with fish oil for 3 months (15 mg docosahexaenoic acid [DHA]/kg body weight daily). ROS was also assessd in 22 age-matched controls. RESULTS: Patients had low n-3 LC-PUFA in plasma phospholipids (DHA, 2.37 +/- 0.10%; eicosapentaenoic acid [EPA], 0.4 +/- 0.03%) and poorer ROS performance than controls (motor development index [MQ] 107 +/- 3 vs 117 +/- 3, P = .010). Supplementation increased phospholipid n-3 LC-PUFA (DHA 7.05 +/- 0.24%; EPA 3.31 +/- 0.19%; P < .001), decreased n-6 LC-PUFA (arachidonic acid, 9.26 +/- 0.23% vs 6.76 +/- 0.16%; P < .001) and improved ROS (MQ 115 +/- 3.54, P = .011, paired t test). ROS was unchanged in 11 retested controls (MQ 115 +/- 5.16, P = NS, paired t test multivariate analysis of variance [MANOVA] for time by group, P = .027). Patients tolerated fish oil well. Plasma phenylalanine remained unchanged. CONCLUSION: In patients with PKU, fish oil supplementation enhances n-3 LC-PUFA levels and improves motor skills.

Fonte: J Pediatr

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