(09-05-07) Body mass index in adolescence predicts coronary artery disease and diabetes in adulthood

Prediabetes 2007:
According to researchers in Israel, increased body mass index in adolescence is associated with an increased risk of coronary artery disease (CAD) and diabetes in adulthood.
Dr Amir Tirosh of the Sheba Medical Center in Tel Hashomer, Israel, and colleagues analyzed data from the Israeli Defense Forces Personnel cohort to determine the relationship between body mass index and the risk of CAD and diabetes in early adulthood. Body mass index was calculated for 11,891 male adolescents aged 17 years. Patients were screened for the incidence of CAD or diabetes during regular visits over the next 20 years.
With a follow-up of 233,302 person-years, 127 individuals developed CAD. A multivariate analysis revealed that the incidence of CAD at the age of 37 years was independently associated with body mass index at age 17 years. The risk of CAD increased as body mass index increased. Those in the highest quintile for body mass index had a 4-fold greater risk of CAD, compared with those in the lowest quintile.
During the follow-up period, 252 individuals developed diabetes. As with CAD, diabetes during adulthood was associated with body mass index in adolescence. Those in the highest quintile for body mass index had a 3-fold increase in the risk of diabetes, compared with those in the lowest quintile.
Dr Tirosh concluded that body mass index in adolescence can predict the risk of developing CAD and diabetes during early adulthood. A body mass index greater than 21.5 kg/m2at age 17 years was found to predict an increased risk of CAD in adulthood, and a body mass index greater then 23.2 kg/ m2was associated with an increased risk of diabetes.

Source: Data presented by A Tirosh at the 2nd International Congress on ?Prediabetes? and the Metabolic Syndrome, Epidemiology, Management and Prevention of Diabetes and Cardiovascular Disease, Barcelona, Spain, 25-28 April 2007.

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