(10-07-07) Regulation of pancreatic beta-cell function by adipocytes.

Zhao YF, Chen C.

Endocrine Cell Biology, Prince Henry's Institute of Medical Research, Melbourne, VIC 3168, Australia; Department of Physiology, the Fourth Military Medical University, Xi'an 710032, China. E-mail: [email protected].

Adipokines, the bioactive factors derived mainly from adipocytes, regulate pancreatic beta-cell function including insulin secretion, gene expression and apoptosis. In this review, we propose that adipokines influence beta-cell function through three interdependent pathways. The first is through regulating lipid and glucose metabolism in beta-cells. The second implicates the change of ion channel opening and closing in beta-cells. The third pathway is via the modification of insulin sensitivity of beta-cells. The endocrine function of adipocytes is dynamic, and the secretion of various adipokines changes under different metabolic conditions. During the progression from the normal state to obesity and to type 2 diabetes, adipokines contribute to the occurrence and development of beta-cell dysfunction in type 2 diabetes.


Fonte: Sheng Li Xue Bao

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