(22-07-07) Body mass index and its effects on retinal vessel diameter in 6-year-old children.

Taylor B, Rochtchina E, Wang JJ, Wong TY, Heikal S, Saw SM, Mitchell P.

1Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, New South Wales, Australia.

Purpose:To examine the relationship between body mass index (BMI) and other anthropometric measures with retinal vessel diameter in children.Methods:A random cluster sample of 34 schools was selected in the Sydney metropolitan area during 2003-04, and 1740 children aged 6 years participated in The Sydney Childhood Eye Study. Retinal images were taken and vessel diameter was measured using a computer-imaging program. Anthropometric measures, including weight, height, waist circumference, BMI and body surface area (BSA), were obtained and defined using standardized protocols. Data on confounders, including ocular parameters, ethnicity, birth parameters and blood pressure, were similarly collected.Results:Mean BMI was 16.2 kg/m(2) (+/-2.1 s.d.) in 1608 (92.4%) children with complete data. After controlling for age, sex, ethnicity, axial length of the eyeball, birth weight and mean arterial blood pressure, children with BMI above the cardiovascular risk threshold (defined as BMI>16.1 kg/m(2) in boys and BMI>15.9 kg/m(2) in girls) had mean retinal venular diameter 2.1 mum larger than those with BMI below this threshold (P=0.026). Increasing weight and BSA were also positively associated with wider retinal venules. Children in the highest quartile of BMI had mean retinal arteriolar diameter 2.2 mum smaller than those in the lowest quartile. Increasing waist circumference and shorter height were also associated with narrower retinal arterioles.Conclusions:In this sample of 6-year-old children, greater BMI, weight and BSA were associated with wider retinal venules, while greater BMI and larger waist circumference were associated with narrower retinal arterioles. These findings suggest a possible effect of increased body mass and adiposity on early microvascular structural alterations in childhood, long before the development of cardiovascular disease.International Journal of Obesity advance online publication, 3 July 2007; doi:10.1038/sj.ijo.0803674.


Fonte: Int J Obes.

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