(29-01-08) Long-Chain Saturated Fatty Acids Consumption and Risk of Gallstone Disease Among Men.

Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL.
From the *Division of Digestive Diseases and Nutrition, University of Kentucky Medical Center, Lexington, Kentucky; ?Channing Laboratory, Department of Medicine, Brigham and Womenʼs Hospital and Harvard Medical School, Boston, Massachusetts; ?Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland; and ?Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts.
BACKGROUND:: Various saturated fatty acids have different effects on blood lipids and insulin secretion in experiments. The effect of long-term consumption of specific and different classes of saturated fatty acids on the risk of gallstone disease in humans is unknown. METHODS:: We prospectively studied consumption of saturated fatty acids and risk of gallstone disease in a cohort of 44,524 US men from 1986 to 2002. Intake of saturated fatty acids was assessed using a validated semiquantitative food frequency questionnaire. Newly diagnosed gallstone disease was ascertained biennially. RESULTS:: During 584,679 person-years of follow-up, we documented 2350 incident cases of gallstone disease, of which 1387 cases required cholecystectomy. Compared with men in the lowest quintile of dietary intake of long-chain saturated fats, after adjustment for age and other potential risk factors, the relative risk of gallstone disease for men in the highest quintile was 1.24 [95% confidence interval (CI), 1.02, 1.50, P for trend = 0.03], and the relative risk of cholecystectomy for men in the highest quintile was 1.41 (CI, 1.09, 1.82, P for trend = 0.008). Consumption of medium-chain saturated fatty acids or short-chain saturated fatty acids was unrelated to the risk. CONCLUSIONS:: Our results suggest that a higher consumption of long-chain saturated fatty acids may enhance the risk of gallstone disease in men.

Source: Ann Surg.

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