(29-01-08) The Effects of Caloric Restriction- and Exercise-Induced Weight Loss on Left Ventricular Diastolic Function.

Riordan MM, Weiss EP, Meyer TE, Ehsani AA, Racette SB, Villareal DT, Fontana L, Holloszy JO, Kovacs SJ.
Biomedical Engineering, Washington University, St. Louis, Missouri, United States.
Little is known about the effects of weight loss on diastolic function (DF). Furthermore, it is not known if both caloric restriction (CR)- and exercise (EX)-induced weight loss have salutary effects on DF. Therefore, we assessed the effects of yearlong CR (n=12) and EX (n=13) interventions, which induced ~12% weight loss, on DF in healthy, non-obese (BMI=23.5-29.9 kg/m(2)) men and women aged 50-60 years. Recordings of Doppler transmitral flow and Doppler tissue imaging were acquired and analyzed by conventional approaches and a validated parameterized diastolic filling (PDF) formalism. Isovolumic relaxation time decreased after weight loss in both groups (p<0.05). Septal E' increased (p<0.01) and E/E' decreased (p<0.05) after weight loss in the CR group. Based on the PDF-derived indices, CR resulted in a decrease in global ventricular stiffness (k) and increases in longitudinal (septal annulus motion) stored elastic strain (xo'), peak force (k'xo'), and peak stored strain energy (1/2k'xo'(2)). In the exercise group, k was unchanged, although septal xo' and 1/2k'xo'(2) increased significantly and k'xo' tended (p=0.13) to increase. We conclude that weight loss, whether induced by caloric restriction or exercise, has salutary effects on DF. Key words: diastolic function, caloric restriction, exercise, weight loss.

Fonte: Am J Physiol Heart Circ Physiol.

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