(15-02-08) Soy protein intake, cardio-renal indices and C-reactive protein in type 2 diabetes with nephropathy: a longitudinal randomized clini

Azadbakht L, Atabak S, Esmaillzadeh A.

Department of Nutrition, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Several short-term trials on the effect of soy consumption on cardiovascular risks are available, but little evidence exists regarding the impact of long-term soy protein consumption among type 2 diabetic patients with nephropathy. Objectives: To determine the effects of long-term soy consumption on cardiovascular risks, C-reactive protein and kidney-function indices among type 2 diabetic patients with nephropathy. Design: This longitudinal randomized clinical trial was conducted among 41 type 2 diabetic patients with nephropathy (18 men and 23 women). Twenty patients in soy protein group consumed a diet containing 0.8 g protein/kg body weight (35% animal proteins, 35% textured soy protein, and 30% vegetable proteins) and 21 patients in control group consumed a similar diet containing 70% animal proteins and 30% vegetable proteins for 4-years. Results: Soy protein consumption significantly affected cardiovascular risks like fasting plasma glucose (mean change in soy vs. control groups: -18+/-3 vs. 11+/-2 mg/dl; P=0.03), total cholesterol (-23+/-5 vs.10+/-3 mg/dl; P=0.01), LDL-C (-20+/-5 vs. 6+/-2 mg/dl; P=0.01), and serum triglyceride concentrations (-24+/-6 vs. -5+/-2 mg/dl; P=0.01). Serum CRP levels was significantly decreased by soy protein intake as compared to control group (1.31+/-0.6 vs. 0.33+/-0.1 mg/L; P=0.02). Significant improvements were also seen in proteinuria (-0.15+/-0.03 vs. 0.02+/-0.01 g/d; P=0.001) and urinary creatinine (-1.5+/-0.9 vs. 0.6+/-0.3 mg/dl, P=0.01) by consuming soy protein. Conclusions: Longitudinal soy protein consumption significantly affected cardiovascular risk factors and kidney-related biomarkers among type 2 diabetic patients with nephropathy.

Source: Diabetes Care.

News

---

In evidenza

"L'informazione presente nel sito serve a migliorare, e non a sostituire, il rapporto medico-paziente."

Per coloro che hanno problemi di salute si consiglia di consultare sempre il proprio medico curante.