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(18-04-08) High prevalence of hypogonadotropic hypogonadism in men referred for obesity treatment.



Hofstra J, Loves S, van Wageningen B, Ruinemans-Koerts J, Jansen I, de Boer H.

Department of Internal Medicine, Rijnstate Hospital, Arnhem, the Netherlands.

Background: Obesity can be associated with biochemical evidence of isolated hypogonadotropic hypogonadism (IHH) in men. Prevalence and severity of IHH in obese men are not exactly known. Objective: To assess the prevalence of IHH in obese men. Design and Subjects: Cross-sectional study of 160 obese men, BMI >30 kg/m2, who applied for medical or surgical treatment of obesity in a general teaching hospital. Main outcome measures: Total and calculated free testosterone (TT and FT) in relation to body mass index (BMI). Results: Mean age of the study population was 43.3 +/- 0.8 years (mean +/- SEM), BMI ranged from 30.0 to 65.7 kg/m2. TT and FT levels were inversely related to BMI (-0.48, p.

Source: Neth J Med. 2008 Mar;66(3):103-9.

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