(04-07-08) CALORIE RESTRICTION MODULATES INACTIVITY-INDUCED CHANGES IN THE INFLAMMATORY MARKERS CRP AND PTX3.

Bosutti A, Malaponte G, Zanetti M, Castellino P, Heer M, Guarnieri G, Biolo G.

Department of Clinical, Technological and Morphological Sciences, Division of Internal Medicine, University of Trieste, Italy; Department of Biomedical Sciences, University of Catania, Italy; Department of Internal Medicine, University of Catania, Italy; DLR-Institute of Aerospace Medicine, Cologne, Germany.
Context. Energy balance and physical activity potentially influence systemic inflammation. Objective. To test the hypothesis that moderate energy restriction may prevent activation of inactivity-induced inflammatory response. Design. Participants were studied four times at the end of 14-day periods of experimental bed rest or controlled ambulation, after receiving eucaloric or hypocaloric diets. Setting. Clinical research center of German Space Agency. Subjects. Nine healthy young volunteers. Interventions. Energy intake was calibrated to physical activity and decreased by about 20% in hypocaloric conditions. Main Outcome Measures. Changes in body fat by DXA as well as plasma inflammatory markers and cytokine mRNA levels in blood cells. Results. Fat mass did not change significantly in eucaloric conditions and decreased in hypocaloric periods (-1.0+/-0.3 and -1.0+/-0.3 kg in ambulatory and bed rest, respectively). Bed rest in eucaloric conditions increased plasma C-reactive protein (CRP) (+143+/-53%) and both the ratios between plasma interleukin-6 (IL-6) and interleukin-10 (IL-10) (4+/-1 times) and white blood cell IL-6 and IL-10 mRNAs (5+/-1 times). Energy restriction prevented bed rest-mediated increases in CRP and IL-6-to-IL-10 ratio. Bed rest increased (P=0.03) long pentraxin-3 (PTX3) plasma concentration, without significant activity-by-diet interaction. In all conditions (n=36), CRP and PTX3 were inversely correlated (r=-0.61, p<0.001). Changes in fat mass, leptin and IL-6 directly correlated with CRP and inversely correlated with PTX3. IL-10 inversely correlated with CRP and directly correlated with PTX3 (r=0.52, P<0.01). Conclusions. Calorie restriction prevents the inflammatory response induced by 14 days of bed rest. We suggest an inverse regulation of CRP and PTX3 in response to changes in energy balance.

Source: J Clin Endocrinol Metab. 2008 May 20.

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