(14-12-08) Insulin Resistance and High Sensitivity C-Reactive Protein in Migraine

Baburhan Guldiken A1, Sibel Guldiken A2, Muzaffer Demir A3, Nilda Turgut A1, Levent Kabayel A4, Hulya Ozkan A4, Emine Ozcelik A5, Armagan Tugrul A2

A1 Department of Neurology, Medical Faculty of Trakya University, Turkey
A2 Department of Endocrinology, Medical Faculty of Trakya University, Edirne, Turkey
A3 Department of Hematology, Medical Faculty of Trakya University, Turkey
A4 Department of Neurology, Social Security Hospital, Edirne, Turkey
A5 Department of Biochemistry, Social Security Hospital, Edirne, Turkey
Abstract:

Background: A relationship between migraine and vascular disorders such as hypertension, stroke, and coronary ischemia has been recently reported. Insulin resistance and endothelial dysfunction, which commonly underlies these disorders, have not been widely investigated in migraine patients. In this study, we aimed to investigate the existence of insulin resistance and endothelial dysfunction, and their relationship to vascular risk factors in patients with migraine. Methods: We evaluated insulin resistance and high-sensitivity C-reactive protein (hs-CRP), a marker of endothelial dysfunction, in 60 migraine patients and 25 healthy control subjects. Multiple analysis of covariance test was used to adjust for known confounding factors that can influence insulin metabolism and endothelial function, such as obesity, blood pressure, and lipid parameters. Results: Insulin resistance, as measured homeostasis model assessment (HOMA)-R levels, was significantly higher in the migraine group (p<0.001). After adjustment for confounding variables, the relationship between migraine and the HOMA-R levels remained significant (p<0.001). The hs-CRP levels did not differ between the migraine and control groups. Conclusions: Our data show that insulin resistance is present in migraine patients. Endothelial dysfunction is not found during the headache-free period. Further studies are needed to explain the role of insulin resistance in migraine pathogenesis.

Source: The Canadian Journal of Neurological Sciences

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