(13-02-09) A Prospective Study of Zinc Intake and Risk of Type 2 Diabetes in Women.

Sun Q, van Dam RM, Willett WC, Hu FB.
From the Departments of Nutrition (QS, RWCW, and FBH) and of Epidemiology (WCW and FBH), Harvard School of Public Health, Boston, MA; the Channing Laboratory (RMD, WCW, and FBH), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Objective- The aim of this study is to investigate the intake of zinc in relation to risk of type 2 diabetes in U.S. women. Research design and methods- Dietary intakes of zinc and other nutrients were assessed and updated using of a validated food frequency questionnaire from 1980 to 2002 among 82,297 women who were aged 33-60 years at baseline in 1980 and followed up to 2004 in the Nurses' Health Study. Results- During the 24 years of follow-up, 6,030 incident cases of type 2 diabetes were ascertained. After adjustment of lifestyle and dietary risk factors, the relative risks of type 2 diabetes (95% CI) comparing the highest with the lowest quintiles were 0.90 (0.82, 0.99, P(trend) = 0.04) for total zinc intake and 0.92 (0.84, 1.00, P(trend) = 0.009) for dietary zinc intake from food sources, respectively. We further found an inverse association for dietary zinc to heme iron ratio. After multivariate adjustment of covariates, the relative risks (95% CI) across quintiles of this ratio were 1.0 (reference), 0.93 (0.86, 1.01), 0.86 (0.79, 0.94), 0.82 (0.75, 0.90), and 0.72 (0.66, 0.80; P(trend) < 0.0001), respectively. Conclusions- Higher zinc intake may be associated with a slightly lower risk of type 2 diabetes in women. More studies are warranted to confirm this association and to explore potential mechanisms.

Source: Diabetes Care. 2009 Jan 26

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