(14-02-09) Results From thePeriodontitis and Vascular Events (PAVE) Study:

A Pilot Multicentered, Randomized, Controlled Trial to Study Effects of Periodontal Therapy in a Secondary Prevention Model of Cardiovascular Disease.



Offenbacher S, Beck JD, Moss K, Mendoza L, Paquette DW, Barrow DA, Couper DJ, Stewart DD, Falkner KL, Graham SP, Grossi S, Gunsolley JC, Madden T, Maupome G, Trevisan M, Van Dyke TE, Genco RJ.
* Center for Oral and Systemic Diseases, Department of Periodontology, University of North Carolina at Chapel Hill, Chapel Hill, NC., dagger Center for Oral and Systemic Diseases, Department of Dental Ecology, University of North Carolina at Chapel Hill., double dagger Center for Oral and Systemic Diseases, North Carolina Oral Health Institute, University of North Carolina at Chapel Hill., section sign Department of Biostatistics, University of North Carolina at Chapel Hill., || Departments of Oral Biology and Microbiology, University at Buffalo, Buffalo, NY., paragraph sign Department of Clinical Medicine, University at Buffalo., # Department of Pediatrics, Brody School of Medicine, East Carolina University, Greenville, NC., ** Department of Periodontics, Virginia Commonwealth University, Richmond, VA., daggerdagger Department of Periodontology, Oregon Health and Science University, Portland, OR., double daggerdouble dagger Department of Public Health and Psychosocial Studies, Auckland University of Technology, Auckland, New Zealand., section sign section sign Department of Preventive and Community Dentistry, Indiana University, Indianapolis, IN., || || Department of Social and Preventive Medicine, University at Buffalo., paragraph sign paragraph sign Department of Periodontology and Oral Biology, Boston University, Boston, MA.
Background: In the Periodontitis and Vascular Events (PAVE) pilot study, periodontal therapy was provided as an intervention in a secondary cardiac event prevention model through five coordinated cardiac-dental centers. Methods: Subjects were randomized to either community care or protocol provided scaling and root planing to evaluate effects on periodontal status and systemic levels of high-sensitivity C-reactive protein (hs-CRP). Results: After 6 months, there was a significant reduction in mean probing depth and extent of 4- or 5-mm pockets. However, there were no significant differences in attachment levels, bleeding upon probing, or extent of subgingival calculus comparing subjects assigned to protocol therapy (n = 151) to those assigned to community care (n = 152). Using intent-to-treat analyses, there was no significant effect on serum hs-CRP levels at 6 months. However, 48% of the subjects randomized to community care received preventive or periodontal treatments. Secondary analyses demonstrated that consideration of any preventive or periodontal care (i.e., any treatment) compared to no treatment showed a significant reduction in the percentage of people with elevated hs-CRP (values >3 mg/l) at 6 months. However, obesity nullified the periodontal treatment effects on hs-CRP reduction. The adjusted odds ratio for hs-CRP levels >3 mg/l at 6 months for any treatment versus no treatment among non-obese individuals was 0.26 (95% confidence interval: 0.09 to 0.72), adjusting for smoking, marital status, and gender. Conclusion: This pilot study demonstrated the critical role of considering obesity as well as rigorous preventive and periodontal care in trials designed to reduce

Source: J Periodontol. 2009 Feb;80(2):190-201

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