(14-05-09) Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers1,2,3,4

Armin Zittermann, Sabine Frisch, Heiner K Berthold, Christian G?tting, Joachim Kuhn, Knut Kleesiek, Peter Stehle, Heinrich Koertke and Reiner Koerfer

1 From the Klinik f?r Thorax- und Kardiovaskularchirurgie (AZ, SF, HK, and RK) and Institut f?r Laboratoriums- und Transfusionsmedizin (CG, JK, and KK), Herzzentrum NRW, Ruhr Universit?t Bochum, Bad Oeynhausen, Germany; Charit?- Universit?tsmedizin Berlin, Interdisziplin?res Stoffwechsel-Centrum; Lipidambulanz, Lipidapherese und Ern?hrungsmedizin Berlin, Germany (HKB); and Institut f?r Ern?hrungs- und Lebensmittelwissenschaften, Universit?t Bonn, Bonn, Germany (PS).
2 AZ and SF contributed equally to this work.
3 Supported by different German health insurance companies and the ?Institut f?r Angewandte Telemedizin,? Herzzentrum NRW, Ruhr Universit?t Bochum, Bad Oeynhausen, Germany. Vitamin D was provided by Merck KgaA, Darmstadt, Germany.
4 Reprints not available. Address correspondence to A Zittermann, Klinik f?r Thorax- und Kardiovaskularchirurgie, Herzzentrum Nordrhein-Westfalen, Georgstra?e 11, 32545 Bad Oeynhausen, Germany. E-mail: [email protected] .
Background: High blood concentrations of parathyroid hormone and low concentrations of the vitamin D metabolites 25-hydroxyvitamin D [25(OH)D] and calcitriol are considered new cardiovascular disease risk markers. However, there is also evidence that calcitriol increases lipogenesis and decreases lipolysis.
Objective: We investigated the effect of vitamin D on weight loss and traditional and nontraditional cardiovascular disease risk markers in overweight subjects.
Design: Healthy overweight subjects (n = 200) with mean 25(OH)D concentrations of 30 nmol/L (12 ng/mL) received vitamin D (83 ?g/d) or placebo in a double-blind manner for 12 mo while participating in a weight-reduction program.
Results: Weight loss was not affected significantly by vitamin D supplementation (?5.7 ? 5.8 kg) or placebo (?6.4 ? 5.6 kg). However, mean 25(OH)D and calcitriol concentrations increased by 55.5 nmol/L and 40.0 pmol/L, respectively, in the vitamin D group but by only 11.8 nmol/L and 9.3 pmol/L, respectively, in the placebo group (P < 0.001), whereas a more pronounced decrease occurred in the vitamin D group than in the placebo group in blood concentrations of parathyroid hormone (?26.5% compared with ?18.7%; P = 0.014), triglycerides (?13.5% compared with +3.0%; P < 0.001), and the inflammation marker tumor necrosis factor- (?10.2% compared with ?3.2%; P = 0.049). The beneficial biochemical effects were independent of the loss in body weight, fat mass, and sex. However, compared with placebo, vitamin D supplementation also increased LDL-cholesterol concentrations (+5.4% compared with ?2.5%; P < 0.001).
Conclusions: The results indicate that a vitamin D supplement of 83 ?g/d does not adversely affect weight loss and is able to significantly improve several cardiovascular disease risk markers in overweight subjects with inadequate vitamin D status participating in a weight-reduction program. This trial was registered at clinicaltrials.gov as NCT00493012.

Source: ajcn

News

---

In evidenza

"L'informazione presente nel sito serve a migliorare, e non a sostituire, il rapporto medico-paziente."

Per coloro che hanno problemi di salute si consiglia di consultare sempre il proprio medico curante.