(18-06-09) Inverse association between dairy intake and hypertension: the Rotterdam Study1,2

Marielle F Engberink, Marieke AH Hendriksen, Evert G Schouten, Frank JA van Rooij, Albert Hofman, Jacqueline CM Witteman and Johanna M Geleijnse

1 From the Division of Human Nutrition, Wageningen University and Research Centre, Wageningen, Netherlands (MFE, MAHH, EGS, and JMG), and the Department of Epidemiology & Biostatistics, Erasmus Medical Centre, Rotterdam, Netherlands (MFE, FJAvR, AH, and JCMW).
2 Address correspondence to MF Engberink, Wageningen University, Division of Human Nutrition, PO Box 8129, 6700 EV Wageningen, Netherlands. E-mail: [email protected] .
Background: Little is known about the effect of different types of dairy food products on the development of hypertension.
Objective: The objective was to determine whether the incidence of hypertension in older Dutch subjects is associated with intake of dairy products.
Design: We examined the relation between dairy intake and incident hypertension in 2245 participants of the Rotterdam Study aged 55 y with complete dietary and blood pressure data, who were free of hypertension at baseline (1990?1993). Blood pressure was reexamined in 1993?1995 and in 1997?1999. Hazard ratios (HRs) with 95% CIs for 2- and 6-y incidence of hypertension were obtained in quartiles of energy-adjusted dairy intake, with adjustment for age, sex, BMI, smoking, educational level, dietary factors, and intake of alcohol and total energy.
Results: Risk of hypertension after 2 y of follow-up (664 incident cases) was inversely associated with dairy product intake. After adjustment for confounders, HRs (95% CIs) were 1.00, 0.82 (0.67, 1.02), 0.67 (0.54, 0.84), and 0.76 (0.61, 0.95) in consecutive quartiles of total dairy product intake (P for trend = 0.008). Corresponding HRs for low-fat dairy products were 1.00, 0.75 (0.60, 0.92), 0.77 (0.63, 0.96), and 0.69 (0.56, 0.86) (P for trend = 0.003). Analysis of specific types of dairy products showed an inverse association with milk and milk products (P for trend = 0.07) and no association with high-fat dairy or cheese (P > 0.6). After 6 y of follow-up (984 incident cases), the associations with hypertension were attenuated to risk reductions of 20% for both total and low-fat dairy products between the extreme quartiles of intake (P for trend = 0.07 and 0.09, respectively).
Conclusion: Intake of low-fat dairy products may contribute to the prevention of hypertension at an older age.

Source: Am J Clin Nutr 89: 1877-1883, 2009.

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