(18-09-09) Biological Variability of Blood Omega-3 Biomarkers.

Harris WS, Thomas RM.
Metabolism and Nutrition Research Center, Sanford Research/USD and Sanford School of Medicine, Sioux Falls, SD.


We conducted a pilot study to estimate the biological variability and effects of a prior meal on the omega-3 fatty acid (FA) content of red blood cells (RBCs), plasma and plasma phospholipids (PL) in 20 healthy volunteers tested weekly over 6 weeks. The within-subject coefficients of variation were 4.1%+/-1.9%, 15.9%+/-6.4%, and 14.5%+/-8.4%, respectively (RBC vs. others, p<0.001). RBC omega-3 FA content had the lowest biological variability and was not altered in the fed state, suggesting that, of the sample types tested, RBCs may be the preferred sample type for assessing omega-3 FA status.

Source: Clin Biochem. 2009 Sep 2

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