(22-09-09) NF-kappaB signaling as a putative target for omega-3 metabolites in the prevention of age-related macular degeneration (AMD).

Kaarniranta K, Salminen A.
Department of Ophthalmology, Institute of Clinical Medicine, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland; Department of Ophthalmology, University Hospital of Kuopio, P.O. Box 1777, FIN-70211 Kuopio, Finland.

Age-related macular degeneration (AMD) is the major reason of blindness of the elderly all over the world. AMD is characterized by a progressive loss of central vision attributable to degenerative and neovascular changes in the macula, the highly specialized region of the retina responsible for sharp and colour visual acuity. Degeneration and cell death of retinal pigment epithelial cells (RPE) cause secondarily adverse effects on neural retina leading to visual loss. Most AMD patients cannot benefit from any treatment modalities. The prevalence of AMD is rising as a consequence of the aging of the population. As the RPE cells age, they are subject to continued oxidative stress and this believed to induce inflammation and progression of AMD. Interestingly, many clinical trials have revealed that dietary intakes of omega-3 fatty acids can reduce the risk of both early and late AMD, although their molecular targets in cellular signaling in AMD pathology are not understood. Recently, it has been proposed that the omega-3 fatty-acid metabolites, resolvins and protectins, function as endogenous anti-inflammatory compounds. In this review, we propose that resolvins and protectins mediate their beneficial effects by preventing NF-kappaB signalling and this that may represent a new target for regulating the inflammatory responses in AMD.

Source: Exp Gerontol. 2009 Sep 11

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