(19-10-09) Abdominal visceral adiposity in the first trimester predicts glucose intolerance in later pregnancy.

Martin AM, Berger H, Nisenbaum R, Lausman AY, MacGarvie S, Crerar C, Ray JG.
Department of Obstetrics and Gynecology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.


OBJECTIVE: To assess whether abdominal adiposity in early pregnancy is associated with a higher risk of glucose intolerance at a later gestational stage. RESEARCH DESIGN AND METHODS: Subcutaneous and visceral fat was measured with ultrasonography at approximately 12 weeks' gestation. A 50-g glucose challenge test (GCT) was performed between 24 and 28 weeks' gestation. The risk of having a positive GCT (>or=7.8 mmol/l) was determined in association with
subcutaneous and visceral adipose tissue depths above their respective upper-quartile values relative to their bottom three quartile values. RESULTS: Sixty-two women underwent GCTs. A visceral adipose tissue depth above the upper quartile value was significantly associated with a positive GCT in later pregnancy (adjusted odds ratio 16.9 [95% CI 1.5-194.6]). No associations were
seen for subcutaneous adipose tissue. CONCLUSIONS: Measurement of visceral adipose tissue depth in early pregnancy may be associated with glucose intolerance later in pregnancy.


Source: Diabetes Care. 2009 Jul;32(7):1308-10.

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